Ilomedin (Iloprost Trometamol)

Iloprost Trometamol, the active ingredient in Ilomedin, is a prostacyclin analog presented as a solution for injection for intravenous use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis.

GNH USA supplies Ilomedin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Ilomedin, a prostacyclin analog, is used in conditions affecting the pulmonary vasculature and microcirculation.

Pulmonary arterial hypertension: improves exercise capacity and hemodynamic parameters. Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.

Ilomedin may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects: - Headache - Flushing - Nausea - Jaw pain - Hypotension - Infusion site pain

Serious or Rare Side Effects: - Severe hypotension - Pulmonary edema - Bleeding complications - Thrombocytopenia - Cardiac arrhythmias

Prior to initiating Ilomedin therapy, several precautions should be observed to ensure patient safety.

Monitor blood pressure: watch for hypotension during and after infusion. Assess bleeding risk: avoid in patients with active hemorrhage or uncontrolled coagulopathy. Pregnancy considerations: limited data; use only if potential benefit justifies potential risk. Hepatic impairment: adjust monitoring as drug clearance may be reduced. Concomitant vasodilators: avoid combined use with other potent vasodilators to prevent additive hypotension. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Ilomedin can interact with other medicines, affecting its safety or efficacy.

Major Interactions (Avoid): - Other prostacyclin analogs: additive vasodilatory effects may cause severe hypotension. - Phosphodiesterase‑5 inhibitors: increased risk of marked blood pressure reduction. - Anticoagulants: heightened bleeding tendency.

Moderate Interactions (Monitor Closely): - Nitrates: may enhance vasodilation and cause hypotension. - Beta‑blockers: may blunt desired hemodynamic response.