GNH USA

Europe — EMA

Ilomedin (Iloprost Trometamol)

GNH USA supplies Ilomedin (Iloprost Trometamol), a prostacyclin analog indicated for pulmonary arterial hypertension and digital ulcers associated

Iloprost Trometamol

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What is Iloprost Trometamol?

Iloprost Trometamol, the active ingredient in Ilomedin, is a prostacyclin analog presented as a solution for injection for intravenous use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis in adult patients. Ilomedin is authorized in the European Union and is supplied as a sterile injectable solution.

GNH USA supplies Ilomedin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

What is Iloprost Trometamol used for?

Ilomedin is a prostacyclin analog that acts on the pulmonary vascular pathway to provide vasodilation and improve microcirculation.

Pulmonary arterial hypertension: improves functional class, exercise capacity and hemodynamic parameters. Digital ulcers associated with systemic sclerosis: accelerates ulcer healing and reduces the formation of new ulcers. Raynaud's phenomenon: decreases frequency and severity of vasospastic attacks.

What are the side effects of Iloprost Trometamol?

Ilomedin may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects: - Headache - Flushing - Nausea - Jaw pain or discomfort

Serious or Rare Side Effects: - Severe hypotension - Pulmonary edema - Clinically significant bleeding events

What precautions apply to Iloprost Trometamol?

When using Ilomedin, clinicians should consider several safety measures.

Monitor blood pressure: watch for hypotensive episodes during and after infusion. Avoid use in recent major hemorrhage: increased bleeding risk. Caution in heart failure: may exacerbate fluid overload. Adjust in renal impairment: dose titration may be required. Contraindicated in known hypersensitivity to iloprost or formulation components. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Iloprost Trometamol interact with?

Ilomedin can interact with other medicines that affect vascular tone or coagulation.

Major Interactions (Avoid): - Concomitant nitrates or other potent vasodilators: risk of severe hypotension. - Anticoagulants (e.g., warfarin, heparin): heightened bleeding tendency. - Phosphodiesterase‑5 inhibitors: additive vasodilatory effect.

Moderate Interactions (Monitor Closely): - Calcium channel blockers: may modestly lower blood pressure. - Beta‑blockers: can mask tachycardia associated with hypotension. - NSAIDs: may affect renal function and fluid balance.

Frequently asked questions

What is Ilomedin used for?+
Ilomedin is an injectable prostacyclin analog indicated for the treatment of pulmonary arterial hypertension and for the management of digital ulcers associated with systemic sclerosis. It helps lower pulmonary vascular resistance and promotes healing of ischemic skin lesions.
How does Iloprost Trometamol work?+
Iloprost Trometamol selectively binds to the IP (prostacyclin) receptor on vascular smooth‑muscle cells, raising intracellular cyclic AMP. This leads to vasodilation of pulmonary and systemic arteries, inhibition of platelet aggregation, and improved endothelial function, which together reduce pulmonary arterial pressure.
What is the usual dose of Ilomedin?+
The dosing regimen for Ilomedin is individualized by the prescribing physician. It is typically started at a low infusion rate and titrated upward based on clinical response and tolerability, with adjustments made according to blood pressure and symptom control.
Is Ilomedin safe in pregnancy or breastfeeding?+
Safety data for Ilomedin during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Ilomedin from GNH USA?+
To order Ilomedin, submit an enquiry on the product page at gnh-usa.com indicating the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Ilomedin compare with the main alternative drug or class?+
Ilomedin (iloprost) is a prostacyclin analog similar to epoprostenol and treprostinil. Compared with epoprostenol, iloprost has a longer half‑life and can be administered via intermittent IV infusion rather than continuous infusion, offering more flexibility. All share vasodilatory and antiplatelet effects but differ in administration routes and stability.
How should Ilomedin be stored and handled?+
Ilomedin must be stored refrigerated at 2‑8 °C, protected from light, and must never be frozen or shaken. The solution should be kept in its original container until use, and any unused portion should be discarded according to local regulations.
How is Ilomedin administered?+
Ilomedin is supplied as a sterile solution for injection and is administered intravenously. It is usually given as a continuous infusion over a defined period, with the rate adjusted by the clinician based on patient response and tolerability.
What are the most serious risks to watch for with Ilomedin?+
The most serious adverse events include severe hypotension, pulmonary edema, and significant bleeding. Patients should be monitored closely for sudden drops in blood pressure, respiratory distress, or signs of hemorrhage during and after infusion.
Who should not use Ilomedin?+
Ilomedin is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, and it should be avoided in individuals with recent major bleeding, uncontrolled severe heart failure, or severe hypotension.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Iloprost Trometamol
Route
Intravenous Use
Manufacturer
Bayer Hellas Sa
Origin
EU

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