GNH USA

Europe — EMA

Idilla

GNH USA supplies Idilla (Dienogest/Estradiol Valerate), a combined oral contraceptive for contraception and menstrual cycle regulation.

Dienogest, Estradiol Valerate

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What is Dienogest, Estradiol Valerate?

Dienogest/Estradiol Valerate, the active ingredient in Idilla, is a combined oral contraceptive presented as an oral tablet for oral use. It provides hormonal contraception and helps regulate the menstrual cycle in women of reproductive age.

GNH USA supplies Idilla as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Dienogest, Estradiol Valerate used for?

Idilla, a combined oral contraceptive, is used to manage hormonal contraception and menstrual cycle regulation.

- Contraception: Prevents pregnancy by inhibiting ovulation and altering cervical mucus. - Menstrual cycle regulation: Reduces irregular bleeding and stabilises cycle length. - Endometriosis‑related pain: Alleviates pain associated with endometriosis by suppressing estrogen‑driven tissue growth.

What are the side effects of Dienogest, Estradiol Valerate?

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: tension‑type or migraine‑like pain. - Breast tenderness: temporary swelling or discomfort. - Spotting or breakthrough bleeding: irregular light bleeding. - Weight change: slight increase or decrease. - Mood changes: irritability or mild depressive symptoms.

Serious or Rare Side Effects: - Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism. - Stroke or transient ischaemic attack. - Myocardial infarction: heart attack risk, especially in smokers. - Severe allergic reaction: anaphylaxis, rash, or angioedema. - Liver dysfunction: jaundice or abnormal liver enzymes. - Hyperglycaemia: elevated blood sugar in susceptible individuals.

What precautions apply to Dienogest, Estradiol Valerate?

Before prescribing Idilla, clinicians should evaluate individual risk factors and contraindications. - Pregnancy: contraindicated (Category X); do not use during pregnancy. - Smoking: avoid in women over 35 who smoke due to increased cardiovascular risk. - Cardiovascular disease: assess history of thromboembolism, stroke, or myocardial infarction. - Liver disease: use with caution in patients with hepatic impairment. - Migraine with aura: avoid because of heightened stroke risk. - Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

What does Dienogest, Estradiol Valerate interact with?

Idilla may interact with several medicines that alter hormone metabolism or clotting pathways.

Major Interactions (Avoid): - Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): markedly reduce contraceptive efficacy. - Anticoagulants (e.g., warfarin): may increase risk of thrombosis. - Certain antiepileptics (e.g., phenytoin): decrease hormone levels, compromising contraception.

Moderate Interactions (Monitor Closely): - Antibiotics such as tetracycline or metronidazole: possible modest reduction in effectiveness. - Herbal supplements (e.g., St. John's wort): may lower plasma hormone concentrations. - Antifungal agents (e.g., ketoconazole): can raise hormone levels, increasing side‑effect risk.

Frequently asked questions

What is Idilla used for?+
Idilla is a prescription combined oral contraceptive that provides reliable birth control and helps regulate irregular menstrual cycles. It is also employed in the management of estrogen‑dependent conditions such as endometriosis‑related pain.
How does Dienogest/Estradiol Valerate work in Idilla?+
The progestogen dienogest suppresses the luteinising hormone surge, preventing ovulation, while estradiol valerate supplies a stable estrogen level. Together they thicken cervical mucus and alter the endometrium, creating an environment that is unfavourable for fertilisation and implantation.
What is the usual dose of Idilla?+
The dosing regimen for Idilla is determined by the prescribing clinician based on the product’s labeling and the patient’s individual needs. Patients should follow the prescriber’s instructions and not alter the schedule without medical advice.
Is Idilla safe to use during pregnancy or breastfeeding?+
Idilla is classified as Pregnancy Category X, meaning it must not be used during pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as hormonal exposure may affect milk production and infant health.
How do I order Idilla from GNH USA?+
To order Idilla, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Idilla compare with other combined oral contraceptives?+
Idilla combines dienogest, a third‑generation progestogen with a favourable bleeding profile, and estradiol valerate, an estrogen that mimics natural estradiol. Compared with older formulations that use ethinyl‑estradiol, Idilla may offer a more physiological estrogen exposure and potentially lower risk of estrogen‑related side effects.
What are the storage requirements for Idilla?+
Idilla tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.
How is Idilla administered?+
Idilla is taken orally once daily, preferably at the same time each day, with or without food. The typical regimen follows a 21‑day active tablet sequence followed by a 7‑day hormone‑free interval, during which withdrawal bleeding occurs.
What are the most serious risks associated with Idilla?+
The most serious risks include venous thromboembolism, stroke, myocardial infarction, and severe allergic reactions. Women with a history of clotting disorders, cardiovascular disease, smoking over age 35, or migraine with aura should avoid using Idilla.
Who should not use Idilla?+
Idilla is contraindicated in pregnant women, individuals with known or suspected breast cancer, active liver disease, uncontrolled hypertension, a history of thromboembolic events, and smokers over 35 years of age. It should also be avoided in women with migraine with aura.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Dienogest, Estradiol Valerate
Route
Oral Use
Manufacturer
Farmitalia S.R.L.
Origin
EU

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