Icoziss

Calcium chloride dihydrate, the active ingredient in Icoziss, is a calcium salt presented as a calcium salt for extracorporeal use. It treats hypocalcemia and provides calcium supplementation during dialysis procedures.\n\nGNH India supplies Icoziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, dialysis centres and clinics worldwide.

Icoziss is used as an electrolyte replenisher to correct calcium deficits in clinical settings.\n\nHypocalcemia: restores low serum calcium concentrations to normal ranges.\nDialysis‑associated calcium deficiency: supplies calcium during extracorporeal dialysis to maintain mineral balance.\nRenal osteodystrophy management: supports calcium homeostasis in patients with chronic kidney disease.

Icoziss may cause a range of adverse reactions, most of which are related to changes in calcium levels or infusion characteristics.\n\nCommon Side Effects:\n- Transient hypercalcemia: mild elevation of serum calcium after infusion.\n- Infusion site irritation: redness or discomfort at the access point.\n- Nausea or vomiting: gastrointestinal upset following administration.\n- Muscle cramps: involuntary contractions due to calcium shifts.\n- Hypotension: drop in blood pressure during rapid infusion.\n- Metallic taste: temporary alteration in taste perception.\n\nSerious or Rare Side Effects:\n- Severe hypercalcemia: can lead to cardiac arrhythmias or neurological impairment.\n- Cardiac arrhythmia: abnormal heart rhythm associated with calcium excess.\n- Vascular calcification: deposition of calcium in blood vessels with prolonged exposure.\n- Anaphylactic reaction: rare severe allergic response requiring immediate medical attention.\n- Metabolic alkalosis: disturbance in acid‑base balance due to calcium carbonate formation.

Before using Icoziss, clinicians should consider several safety measures to minimize risk.\n\nMonitor serum calcium: check levels before, during, and after infusion.\nAdjust dose in renal impairment: reduce amount for patients with decreased clearance.\nAvoid rapid infusion: administer at recommended flow rates to prevent cardiovascular stress.\nCaution in hypercalcemia: do not use if serum calcium is already elevated.\nAssess cardiac status: evaluate for existing arrhythmias or heart disease.\nStore at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Calcium chloride dihydrate can interact with other medicines, altering their effectiveness or safety.\n\nMajor Interactions (Avoid):\n- Loop diuretics: increase calcium loss, potentially worsening hypocalcemia.\n- Bisphosphonates: may precipitate severe hypocalcemia when calcium levels drop.\n- Digoxin: elevated calcium can enhance digoxin toxicity.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors: may affect renal handling of calcium.\n- NSAIDs: can impair kidney function, influencing calcium balance.\n- Vitamin D analogues: synergistic effect on calcium absorption, requiring monitoring.