Icoziss

Calcium Chloride Dihydrate, the active ingredient in Icoziss, is a calcium salt / electrolyte presented as a sterile aqueous solution for extracorporeal use. It is employed to correct low calcium levels and to support cardiac and neuromuscular function during procedures that remove blood from the body.

GNH USA supplies Icoziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for import and distribution, ensuring product integrity at each step.

Icoziss is used as an electrolyte replenisher to manage conditions associated with low extracellular calcium.

- Hypocalcemia: restores serum calcium concentrations to normal ranges, helping to prevent neuromuscular irritability and cardiac dysfunction. - Calcium supplementation during extracorporeal procedures: provides calcium ions required for myocardial contractility and coagulation while blood circulates outside the body. - Cardiopulmonary bypass surgery: maintains calcium balance to support hemodynamic stability and reduce the risk of arrhythmias.

Calcium Chloride Dihydrate may be associated with several adverse reactions, ranging from mild to severe.

Common Side Effects: - Infusion site irritation: redness, pain or swelling at the catheter site. - Transient hypercalcemia: temporary elevation of serum calcium that usually resolves with monitoring. - Hypotension: drop in blood pressure during rapid administration. - Nausea or vomiting: gastrointestinal discomfort reported by some patients.

Serious or Rare Side Effects: - Severe hypercalcemia: can lead to cardiac arrhythmias, renal impairment or neurologic symptoms. - Cardiac arrhythmias: ventricular tachycardia or fibrillation triggered by abrupt calcium shifts. - Vascular thrombosis: clot formation at the infusion site. - Allergic reactions: urticaria, bronchospasm or anaphylaxis.

When using Icoziss, clinicians should observe specific safety measures to minimise risks. - Renal impairment: monitor serum calcium and adjust dose to avoid accumulation. - Cardiac disease: watch for arrhythmias and changes in blood pressure during infusion. - Concurrent calcium‑containing medications: avoid excessive calcium load. - Electrolyte imbalance: correct magnesium and phosphate abnormalities before administration. - Pregnancy and lactation: use only if the potential benefit outweighs the risk to mother and fetus. - Store below 25°C: keep in the original container, protect from light and moisture.

Calcium Chloride Dihydrate can interact with several drugs, affecting their efficacy or safety.

Major Interactions (Avoid): - Digitalis glycosides: increased calcium may enhance toxicity, leading to arrhythmias. - Bisphosphonates: calcium can reduce their absorption and therapeutic effect.

Moderate Interactions (Monitor Closely): - Loop diuretics: may increase calcium excretion, requiring closer monitoring of calcium levels. - Calcium channel blockers: additive hypotensive effect may occur. - Antacids containing calcium: risk of hypercalcemia when combined.