GNH USA

Europe — EMA

Icomb 10 Mg/5 Mg (Ramipril, Amlodipine Besilate)

GNH USA supplies Icomb 10 Mg/5 Mg (Ramipril/Amlodipine), an ACE inhibitor and calcium‑channel blocker for hypertension. Request a quote for global supply.

Ramipril, Amlodipine Besilate

Request sourcing

1
Pack/s

What is Ramipril, Amlodipine Besilate?

Ramipril, the active ingredient in Icomb 10 Mg/5 Mg, is an ACE inhibitor presented as a 10 mg/5 mg tablet for oral use. It lowers blood pressure by inhibiting the renin‑angiotensin system and is indicated for the treatment of hypertension in adult patients.

GNH USA supplies Icomb 10 Mg/5 Mg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution for this antihypertensive combination.

What is Ramipril, Amlodipine Besilate used for?

Icomb 10 Mg/5 Mg is used to manage hypertension, a condition involving elevated arterial pressure.

Essential hypertension: improves blood pressure control in patients with primary hypertension. Secondary hypertension: assists in lowering blood pressure when hypertension is caused by another underlying disorder. Hypertension with cardiovascular risk: provides combined ACE inhibition and calcium‑channel blockade to reduce overall cardiovascular strain.

What are the side effects of Ramipril, Amlodipine Besilate?

Common Side Effects: - Cough - Dizziness or light‑headedness - Peripheral edema - Flushing or warmth sensation - Headache - Fatigue

Serious or Rare Side Effects: - Angioedema (swelling of face, lips, tongue) - Severe hypotension - Hepatic enzyme elevation - Myocardial infarction - Cardiac arrhythmias - Neutropenia or other blood dyscrasias

What precautions apply to Ramipril, Amlodipine Besilate?

Before initiating therapy, consider the following precautions.

Monitor blood pressure regularly: ensure therapeutic effect and avoid excessive lowering. Assess renal function: dose adjustment may be needed in renal impairment. Check electrolyte levels: especially potassium, due to ACE‑inhibitor effect. Caution in heart failure patients: monitor for fluid retention. Avoid in patients with known hypersensitivity to ramipril, amlodipine, or any excipients. Store at ambient temperature: keep in the original pack, protect from moisture.

What does Ramipril, Amlodipine Besilate interact with?

Icomb 10 Mg/5 Mg may interact with several medicines; review patient medication lists.

Major Interactions (Avoid): - Aliskiren (dual renin‑angiotensin blockade) - Potassium‑sparing diuretics (risk of hyperkalaemia) - NSAIDs (may blunt antihypertensive effect and affect renal function) - High‑dose simvastatin (increased risk of myopathy) - Strong CYP3A4 inhibitors (e.g., itraconazole) affecting amlodipine levels

Moderate Interactions (Monitor Closely): - Thiazide diuretics (additive blood pressure lowering) - Beta‑blockers (enhanced hypotensive effect) - Lithium (increased lithium levels) - Rifampin (induces metabolism, may reduce efficacy) - Digoxin (monitor serum levels due to possible changes in clearance)

Frequently asked questions

What is Icomb 10 Mg/5 Mg used for?+
Icomb 10 Mg/5 Mg is a prescription tablet that combines ramipril and amlodipine to treat hypertension. The dual mechanism lowers blood pressure by inhibiting the renin‑angiotensin system and relaxing vascular smooth muscle, providing effective control for adult patients with elevated arterial pressure.
How does ramipril work in Icomb?+
Ramipril is an angiotensin‑converting enzyme (ACE) inhibitor. It blocks the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, leading to reduced vasoconstriction, decreased aldosterone secretion, and ultimately lower systemic blood pressure.
What is the usual dose of Icomb 10 Mg/5 Mg?+
The dosage of Icomb 10 Mg/5 Mg is determined by the prescribing clinician based on the individual’s blood pressure, renal function, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.
Is Icomb safe to use during pregnancy or breastfeeding?+
The safety of Icomb during pregnancy or lactation has not been established. Ramipril is generally contraindicated in pregnancy because of potential fetal toxicity, and amlodipine should be used only if the benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Icomb 10 Mg/5 Mg from GNH USA?+
To request Icomb 10 Mg/5 Mg, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA supplies hospitals, pharmacies, and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.
How does Icomb compare with other antihypertensive options?+
Icomb combines an ACE inhibitor (ramipril) with a calcium‑channel blocker (amlodipine), offering complementary blood‑pressure reduction. Compared with monotherapy, the combination can achieve better control with a single tablet, potentially improving adherence. It differs from other combos such as lisinopril‑hydrochlorothiazide by targeting both the renin‑angiotensin system and vascular calcium channels.
What are the storage and handling requirements for Icomb?+
Icomb tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use after the expiration date printed on the label.
How is Icomb administered?+
Icomb is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.
What are the most serious risks associated with Icomb?+
Serious risks include angioedema (rapid swelling of the face, lips, tongue, or throat), severe hypotension, and hepatic dysfunction. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, sudden dizziness, or signs of liver injury such as jaundice.
Who should not use Icomb 10 Mg/5 Mg?+
Icomb should be avoided in individuals with known hypersensitivity to ramipril, amlodipine, or any tablet excipients. It is also contraindicated in patients with a history of angioedema related to ACE‑inhibitor therapy, severe aortic stenosis, or those taking aliskiren concomitantly if they have diabetes.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Ramipril, Amlodipine Besilate
Route
Oral Use
Manufacturer
Egis Pharmaceuticals Plc
Origin
EU

Related products

Alamut

Alamut

Ramipril, Amlodipine Besilate

So.Se.Pharm S.R.L.
EU
Amirap

Amirap

Ramipril, Amlodipine Besilate

Sandoz Pharmaceuticals D.D.
EU
Egiramlon

Egiramlon

Ramipril, Amlodipine Besilate

Egis Pharmaceuticals Plc
EU
Egiramlon

Egiramlon

Ramipril, Amlodipine Besilate

Egis Pharmaceuticals Plc
EU