GNH USA

Europe — EMA

Icatibant Zentiva Pharma Uk

GNH USA supplies Icatibant Zentiva Pharma Uk (Icatibant), a bradykinin B2 receptor antagonist for hereditary angioedema attacks.

Icatibant

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What is Icatibant?

Icatibant, the active ingredient in Icatibant Zentiva Pharma Uk, is a bradykinin B2 receptor antagonist presented as a subcutaneous formulation for subcutaneous use. It treats hereditary angioedema attacks in patients with a confirmed diagnosis.

GNH USA supplies Icatibant Zentiva Pharma Uk as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Icatibant used for?

Icatibant acts on the bradykinin pathway to control hereditary angioedema and related bradykinin‑mediated swelling. - Hereditary angioedema (HAE) attacks: rapidly reduces swelling and improves airway patency. - Acute HAE episodes: provides prompt relief of symptoms during an attack. - Bradykinin‑mediated angioedema: alleviates swelling caused by excess bradykinin.

What are the side effects of Icatibant?

Icatibant may cause a range of adverse reactions, most of which are related to the injection site or systemic exposure.

Common Side Effects: - Injection site pain: discomfort at the site of subcutaneous administration. - Redness or erythema: localized skin irritation. - Nausea: mild gastrointestinal upset. - Headache: transient cranial discomfort.

Serious or Rare Side Effects: - Hypersensitivity reactions: including rash, urticaria, or anaphylaxis. - Severe hypotension: marked drop in blood pressure requiring medical attention. - Paradoxical angioedema: worsening swelling despite therapy.

What precautions apply to Icatibant?

Before using Icatibant, consider the following safety measures. - Pregnancy: consult a prescriber; limited data are available on fetal safety. - Breastfeeding: weigh potential risks against benefits before administration. - Renal impairment: monitor renal function; dose adjustment may be required. - Concomitant ACE inhibitors or neprilysin inhibitors: increased bradykinin levels may heighten risk of angioedema. - Known hypersensitivity: avoid use if the patient has a documented allergy to icatibant. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Icatibant interact with?

Icatibant can interact with other medicines that influence bradykinin levels or cardiovascular function.

Major Interactions (Avoid): - ACE inhibitors: may amplify bradykinin‑mediated angioedema. - Neprilysin inhibitors: increase circulating bradykinin, raising risk of swelling. - Estrogen‑containing therapies: can potentiate bradykinin effects.

Moderate Interactions (Monitor Closely): - Diuretics: may affect blood pressure when combined with icatibant. - NSAIDs: could increase risk of renal adverse events. - Oral contraceptives: monitor for enhanced bradykinin activity.

Frequently asked questions

What is Icatibant used for?+
Icatibant is prescribed to treat acute attacks of hereditary angioedema (HAE), a rare genetic condition that causes sudden, severe swelling of the skin and mucosal tissues. By blocking the bradykinin B2 receptor, it helps to quickly reduce swelling and restore normal airway function during an HAE episode.
How does icatibant work?+
Icatibant works as a competitive antagonist of the bradykinin B2 receptor. By binding to this receptor, it prevents bradykinin from triggering vasodilation and increased vascular permeability, which are the primary mechanisms that cause the swelling seen in hereditary angioedema attacks.
What is the usual dose of icatibant?+
The dose of icatibant is determined by the prescribing clinician based on the patient’s condition, weight, and clinical response. Typically, a single subcutaneous injection is administered at the onset of an HAE attack, and additional doses may be given if needed under medical supervision.
Is icatibant safe to use during pregnancy or breastfeeding?+
Safety data for icatibant in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing it to pregnant or breastfeeding individuals. The decision is made on a case‑by‑case basis.
How do I order Icatibant Zentiva Pharma Uk from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and any required import documentation.
How does icatibant compare with other hereditary angioedema treatments?+
Icatibant is a bradykinin B2 receptor antagonist, whereas other HAE therapies such as C1‑esterase inhibitor concentrates replace a missing protein, and newer monoclonal antibodies target different pathways. Icatibant offers rapid subcutaneous administration and works directly at the receptor level, making it useful for patients who prefer self‑injection and need quick symptom relief.
What are the storage and handling requirements for icatibant?+
Icatibant should be stored refrigerated between 2 °C and 8 °C. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. If temporary storage at room temperature is unavoidable, limit exposure to no more than 30 °C for a short period.
How is icatibant administered?+
Icatibant is given as a subcutaneous injection, usually into the abdomen or thigh. The injection is performed by a trained healthcare professional or by the patient after proper instruction. The site should be rotated for repeated administrations to minimize local irritation.
What are the most serious risks associated with icatibant?+
The most serious risks include severe hypersensitivity reactions such as anaphylaxis, marked hypotension, and paradoxical worsening of angioedema despite treatment. Patients should be monitored closely after the first dose, and any signs of severe allergic reaction or sudden blood pressure drop require immediate medical attention.
Who should not use icatibant?+
Icatibant is contraindicated in individuals with a known hypersensitivity to the drug or any of its excipients. Patients taking ACE inhibitors, neprilysin inhibitors, or estrogen‑containing therapies should discuss potential risks with their physician, as these medications may increase the likelihood of angioedema.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Icatibant
Route
Subcutaneous Use
Manufacturer
Zentiva Pharma Uk Limited
Origin
EU

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