GNH USA

Europe — EMA

Icatibant Teva

GNH USA supplies Icatibant Teva (Icatibant acetate), a bradykinin B2 receptor antagonist for acute angioedema type I and II attacks. Request a quote.

Icatibant Acetate

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What is Icatibant Acetate?

Icatibant acetate, the active ingredient in Icatibant Teva, is a bradykinin B2 receptor antagonist presented as a 30 mg/0.3 mL prefilled syringe for subcutaneous use. It treats acute attacks of hereditary angioedema type I and type II in patients with a confirmed diagnosis and is indicated for rapid symptom control during life‑threatening swelling episodes.

GNH USA supplies Icatibant Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare facilities worldwide, ensuring quality, regulatory compliance and reliable access to this specialty therapy for qualified providers.

What is Icatibant Acetate used for?

Icatibant Teva is used to manage hereditary angioedema, a bradykinin‑mediated swelling disorder. Hereditary angioedema type I: reduces severity and shortens duration of acute swelling attacks. Hereditary angioedema type II: provides rapid relief of symptoms during acute episodes. Hereditary angioedema attacks (any type): offers prompt control of edema and associated pain.

What are the side effects of Icatibant Acetate?

Icatibant Teva may cause a range of adverse reactions following subcutaneous administration.

Common Side Effects: - Injection site pain: mild to moderate discomfort at the injection site. - Redness: localized erythema around the injection area. - Swelling: transient edema at the site of administration. - Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects: - Hypersensitivity reaction: rash, urticaria, or anaphylaxis requiring immediate medical attention. - Severe abdominal pain: persistent intense pain that may indicate a serious complication. - Thrombocytopenia: rare drop in platelet count observed in post‑marketing reports.

What precautions apply to Icatibant Acetate?

Before using Icatibant Teva, consider the following precautions. Pregnancy: safety not established; use only if potential benefit justifies risk. Breastfeeding: unknown; consider risk versus benefit. Renal impairment: no dosage adjustment required, but monitor closely. Concomitant ACE inhibitors: may increase bradykinin levels; observe for enhanced swelling. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Icatibant Acetate interact with?

Icatibant Teva can interact with other medicines; review the following categories. Major Interactions (Avoid): - ACE inhibitors: additive bradykinin effect may worsen angioedema. - Angiotensin receptor blockers: similar risk of increased bradykinin. Moderate Interactions (Monitor Closely): - Estrogen‑containing contraceptives: may increase frequency of HAE attacks; monitor. - Other B2 receptor antagonists: potential additive effect; observe response. - Immunosuppressants: no direct interaction but monitor infection risk.

Frequently asked questions

What is Icatibant Teva used for?+
Icatibant Teva is indicated for the treatment of acute attacks of hereditary angioedema type I and type II. It provides rapid symptom relief by reducing swelling, pain, and potential airway obstruction associated with these life‑threatening episodes.
How does icatibant acetate work?+
Icatibant acetate acts as a selective antagonist of the bradykinin B2 receptor. By blocking this receptor, it prevents bradykinin‑mediated vasodilation and increased vascular permeability, which are the primary drivers of edema in hereditary angioedema.
What is the usual dose of Icatibant Teva?+
The prescribed dose is determined by the treating physician based on the patient’s condition and clinical guidelines. In practice, a single 30 mg subcutaneous injection is commonly administered for an acute attack, but exact dosing and repeat administration are at the prescriber’s discretion.
Is Icatibant Teva safe during pregnancy or breastfeeding?+
Safety data for Icatibant acetate in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.
How do I order Icatibant Teva from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.
How does Icatibant Teva compare with the main alternative therapy?+
The primary alternative for hereditary angioedema is plasma‑derived or recombinant C1‑esterase inhibitor replacement. Icatibant works by blocking bradykinin receptors, offering a rapid, subcutaneous option, whereas C1‑esterase inhibitors replace the deficient protein and are administered intravenously. Choice depends on patient preference, attack severity and clinical response.
What are the storage and handling requirements for Icatibant Teva?+
Icatibant Teva must be stored refrigerated at 2 °C to 8 °C. Keep the prefilled syringes in the original packaging, protect them from light, and avoid freezing or shaking the product. If temporary temperature excursions occur, consult the product label before use.
How is Icatibant Teva administered?+
The medication is supplied as a prefilled syringe containing 30 mg of icatibant acetate in 0.3 mL. After cleaning the injection site, the syringe is inserted subcutaneously, typically into the abdomen or thigh, and the plunger is depressed to deliver the full dose. Patients should be observed for any immediate reactions.
What are the most serious risks associated with Icatibant Teva?+
Serious adverse events include hypersensitivity reactions such as rash, urticaria, or anaphylaxis, severe abdominal pain, and rare cases of thrombocytopenia. Any signs of a severe allergic response or unexplained intense pain should prompt immediate medical evaluation.
Who should not use Icatibant Teva?+
Icatibant Teva is contraindicated in individuals with known hypersensitivity to icatibant acetate or any of the formulation excipients. Caution is also advised for patients with a history of severe allergic reactions, and it should be used under medical supervision in those with uncontrolled cardiovascular disease.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Icatibant Acetate
Route
Subcutaneous Use
Manufacturer
Teva B.V
Origin
EU

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