Icatibant Ratiopharm

Icatibant acetate, the active ingredient in Icatibant Ratiopharm, is a bradykinin B2 receptor antagonist presented as a subcutaneous injection for subcutaneous use. It treats hereditary angioedema (HAE) attacks in patients with a confirmed diagnosis.

GNH USA supplies Icatibant Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Icatibant Ratiopharm is used to treat conditions mediated by excessive bradykinin activity, primarily hereditary angioedema.

Hereditary angioedema (HAE) attacks: rapid reduction of swelling and pain during acute episodes.

Common Side Effects: - Injection site pain or erythema - Local swelling or induration - Nausea or mild headache - Dizziness or fatigue

Serious or Rare Side Effects: - Hypersensitivity reactions including rash or urticaria - Anaphylaxis or severe allergic response - Marked hypotension - Angioedema unrelated to HAE - Thrombocytopenia or abnormal bleeding - Severe infection at the injection site

Before initiating therapy, confirm the diagnosis of hereditary angioedema and assess for prior hypersensitivity to bradykinin antagonists.

- Allergy assessment: avoid in patients with known B2‑receptor antagonist allergy. - Monitoring: observe for signs of severe hypotension or anaphylaxis after injection. - Concomitant therapy: use under medical supervision when combined with ACE inhibitors or other bradykinin‑modulating agents. - Pregnancy and lactation: discuss potential risks with a healthcare professional before use. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Icatibant may interact with drugs that influence bradykinin levels or vascular tone.

Major Interactions (Avoid): - ACE inhibitors: can increase bradykinin and heighten risk of angioedema. - Neprilysin inhibitors: may elevate bradykinin concentrations. - Other bradykinin B2 antagonists: additive pharmacologic effect.

Moderate Interactions (Monitor Closely): - NSAIDs: may exacerbate swelling or pain. - Oral contraceptives: potential for altered vascular response. - Diuretics: monitor blood pressure changes. - Antihistamines: may mask early signs of hypersensitivity.