GNH USA

Europe — EMA

Icatibant Fresenius (Icatibant Acetate)

GNH USA supplies Icatibant Fresenius (Icatibant Acetate), a bradykinin B2 receptor antagonist for acute hereditary angioedema attacks.

Icatibant Acetate

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What is Icatibant Acetate?

Icatibant Acetate, the active ingredient in Icatibant Fresenius, is a bradykinin B2 receptor antagonist presented as a subcutaneous solution for subcutaneous use. It is indicated for the treatment of acute attacks of hereditary angioedema in patients with C1‑inhibitor deficiency.

GNH USA supplies Icatibant Fresenius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

What is Icatibant Acetate used for?

Icatibant Fresenius is used to treat conditions involving bradykinin‑mediated angioedema.

Acute hereditary angioedema attacks: rapid reduction of swelling during an episode. Hereditary angioedema type I: symptom control during acute episodes. Hereditary angioedema type II: alleviates edema during crises.

What are the side effects of Icatibant Acetate?

Common Side Effects: - Injection site pain or erythema. - Local swelling or induration at the injection site. - Headache. - Nausea. - Dizziness. - Fatigue.

Serious or Rare Side Effects: - Anaphylactic reaction. - Severe hypersensitivity (rash, urticaria). - Angioedema unrelated to hereditary condition. - Hypotension. - Thrombotic events (very rare).

What precautions apply to Icatibant Acetate?

Before initiating therapy, consider the following precautions.

Assess patient history: confirm diagnosis of hereditary angioedema and prior treatment response. Monitor for hypersensitivity: watch for signs of anaphylaxis or severe allergic reactions. Avoid use in patients with known hypersensitivity to icatibant or its excipients. Use with caution in pregnant or breastfeeding women: safety data are limited. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Icatibant Acetate interact with?

Icatibant may interact with other medicines; review patient medication lists.

Major Interactions (Avoid): - ACE inhibitors: concurrent use can increase bradykinin levels and exacerbate angioedema. - Other bradykinin B2 receptor antagonists: may reduce therapeutic effectiveness.

Moderate Interactions (Monitor Closely): - Corticosteroids: may mask early signs of hypersensitivity. - Antihistamines: additive effects on edema control may occur. - Warfarin: monitor INR as vascular changes could affect anticoagulation.

Frequently asked questions

What is Icatibant Fresenius used for?+
Icatibant Fresenius is prescribed to treat acute attacks of hereditary angioedema caused by C1‑inhibitor deficiency. It works by rapidly reducing swelling and relieving symptoms during an episode.
How does Icatibant Acetate work?+
Icatibant Acetate blocks the bradykinin B2 receptor, preventing bradykinin from causing vasodilation and increased vascular permeability. This inhibition stops the cascade that leads to the swelling seen in hereditary angioedema.
What is the usual dose of Icatibant Fresenius?+
The dose and administration schedule are determined by the prescribing healthcare professional based on the patient’s condition and clinical guidelines. Patients should follow the prescriber’s instructions exactly.
Is Icatibant Fresenius safe during pregnancy or breastfeeding?+
Safety in pregnancy and lactation has not been established. The drug should be used only if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.
How do I order Icatibant Fresenius from GNH USA?+
Submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.
How does Icatibant compare with other hereditary angioedema treatments?+
Icatibant is a bradykinin B2 receptor antagonist, whereas other options such as C1‑inhibitor concentrates replace the deficient protein. Icatibant provides a rapid, targeted approach to block bradykinin‑mediated swelling, while C1‑inhibitor therapy works upstream by restoring the regulatory protein.
What are the storage and handling requirements for Icatibant Fresenius?+
The product must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.
How is Icatibant Fresenius administered?+
Icatibant Fresenius is given as a subcutaneous injection, typically into the abdomen or thigh. The injection is performed by a trained healthcare professional or the patient after proper instruction.
What are the most serious risks associated with Icatibant Fresenius?+
Serious risks include anaphylaxis, severe hypersensitivity reactions, and rare cases of systemic angioedema unrelated to hereditary disease. Patients should be monitored for any signs of allergic reaction immediately after injection.
Who should not use Icatibant Fresenius?+
Individuals with known hypersensitivity to icatibant acetate or any of its excipients should avoid the product. It is also contraindicated in patients who have experienced severe allergic reactions to other bradykinin B2 receptor antagonists.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Icatibant Acetate
Route
Subcutaneous Use
Manufacturer
Fresenius Kabi Hungary Kft.
Origin
EU

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