GNH USA

Europe — EMA

Icatibant Aguettant

GNH USA supplies Icatibant Aguettant (Icatibant), a bradykinin B2 receptor antagonist for acute hereditary angioedema attacks in adults. Request a quote.

Icatibant

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What is Icatibant?

Icatibant, the active ingredient in Icatibant Aguettant, is a bradykinin B2 receptor antagonist presented as a solution for injection for subcutaneous use. It treats acute attacks of hereditary angioedema in adults. GNH USA supplies Icatibant Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Icatibant used for?

Icatibant acts on the bradykinin pathway to relieve swelling in hereditary angioedema. - Acute hereditary angioedema attacks: provides rapid reduction of edema in adults. - Hereditary angioedema type I attacks: alleviates swelling severity during episodes. - Hereditary angioedema type II attacks: helps control acute edema episodes.

What are the side effects of Icatibant?

Icatibant may cause a range of adverse reactions.

Common Side Effects: - Injection site pain: mild to moderate discomfort at the injection site. - Redness or erythema: localized skin reddening. - Swelling at injection site: transient local edema. - Nausea: occasional upset stomach. - Headache: mild to moderate. - Dizziness: transient light‑headedness.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Severe hypotension: sudden drop in blood pressure. - Angioedema of other sites: unexpected swelling in face, lips, or airway. - Urticaria: hives or skin rash. - Thrombocytopenia: low platelet count. - Severe allergic reaction: including bronchospasm or respiratory distress.

What precautions apply to Icatibant?

Before using Icatibant, consider the following safety measures. - Pregnancy: safety not established; use only if benefit outweighs risk. - Breastfeeding: unknown safety; evaluate potential risks. - Renal impairment: monitor as clearance may be reduced. - Concomitant ACE inhibitors: increased bradykinin may raise angioedema risk. - Hypersensitivity: discontinue if severe allergic reaction occurs. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Icatibant interact with?

Icatibant may interact with other medicines; review the following.

Major Interactions (Avoid): - ACE inhibitors: additive bradykinin effect may increase angioedema risk. - Renin‑angiotensin system blockers: similar risk of enhanced swelling.

Moderate Interactions (Monitor Closely): - Estrogen‑containing contraceptives: may exacerbate hereditary angioedema. - NSAIDs: can increase swelling propensity. - Other bradykinin antagonists: additive pharmacologic effect.

Frequently asked questions

What is Icatibant Aguettant used for?+
Icatibant Aguettant is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in adult patients. It works to quickly reduce swelling caused by the sudden release of bradykinin during an HAE episode.
How does icatibant work?+
Icatibant blocks the bradykinin B2 receptor, preventing bradykinin from binding and triggering vasodilation and increased vascular permeability. This inhibition stops the cascade that leads to the rapid swelling seen in hereditary angioedema attacks.
What is the usual dose of icatibant?+
The dose of icatibant is determined by the prescribing healthcare professional based on the patient’s condition and clinical guidelines. The prescriber will decide the exact amount and frequency appropriate for each individual case.
Is icatibant safe in pregnancy or breastfeeding?+
Safety data for icatibant during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified clinician.
How do I order Icatibant Aguettant from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.
How does icatibant compare with the main alternative treatment?+
The primary alternative for HAE attacks is C1‑esterase inhibitor replacement therapy. Icatibant acts by blocking bradykinin receptors, offering a rapid sub‑cutaneous option, whereas C1‑esterase inhibitors replace the deficient protein and are administered intravenously. Choice depends on clinical response, patient preference and accessibility.
How should I store Icatibant Aguettant?+
Icatibant should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.
How is Icatibant administered?+
Icatibant is given as a subcutaneous injection, typically into the abdomen or thigh. The injection is performed by a trained healthcare professional or, after appropriate instruction, by the patient or caregiver using the supplied pre‑filled syringe.
What are the most serious risks to watch for?+
Serious adverse reactions include anaphylaxis, severe hypotension, and unexpected angioedema at sites other than the treated area. If any of these occur, immediate medical attention is required and the medication should be discontinued.
Who should not use icatibant?+
Icatibant is contraindicated in individuals with known hypersensitivity to icatibant or any of its excipients. Patients with a history of severe allergic reactions to bradykinin antagonists should avoid its use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Icatibant
Route
Subcutaneous Use
Manufacturer
Laboratoire Aguettant
Origin
EU

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