Icalziss

Calcium chloride dihydrate, the active ingredient in Icalziss, is an electrolyte presented as an aqueous solution for extracorporeal use. It helps restore calcium ion concentrations in patients who require rapid calcium supplementation, such as those undergoing dialysis or cardiac surgery.

GNH USA supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide.

Icalziss is used to address calcium deficits in clinical situations that involve extracellular fluid electrolyte management.

- Hypocalcemia: restores normal serum calcium levels in patients with acute or chronic low calcium. - Renal dialysis: provides calcium replacement during hemodialysis to prevent calcium loss. - Cardiac surgery: supports calcium‑dependent myocardial function during cardiopulmonary bypass. - Massive transfusion: corrects calcium depletion caused by citrate‑containing blood products.

Calcium chloride dihydrate may cause a range of adverse reactions when administered intravenously.

Common Side Effects: - Hypercalcemia: elevated serum calcium levels causing fatigue or nausea. - Infusion site irritation: redness, pain, or swelling at the injection site. - Hypotension: transient drop in blood pressure during rapid infusion. - Nausea or vomiting: gastrointestinal discomfort following administration. - Muscle cramps: involuntary contractions due to calcium fluctuations.

Serious or Rare Side Effects: - Cardiac arrhythmias: irregular heart rhythms, especially in patients with pre‑existing heart disease. - Pulmonary edema: fluid accumulation in the lungs after large volume infusion. - Metabolic alkalosis: disturbance of acid‑base balance. - Severe hypercalcemia: neurological symptoms, confusion, or coma. - Anaphylactic reaction: rare allergic response requiring immediate medical attention.

When using Icalziss, clinicians should observe several safety measures.

- Monitor serum calcium: check levels before, during, and after infusion. - Adjust dose in renal impairment: reduced clearance may increase calcium accumulation. - Cardiac disease caution: avoid rapid infusion in patients with known arrhythmias. - Avoid in hypercalcemia: contraindicated when calcium levels are already elevated. - Infusion rate control: administer slowly to minimize hypotension and irritation. - Store at ambient temperature below 25°C: keep in original container, protect from moisture and direct sunlight.

Calcium chloride dihydrate can interact with several medications, requiring careful management.

Major Interactions (Avoid): - Bisphosphonates: concurrent use may increase risk of hypocalcemia. - Thiazide diuretics: can potentiate hypercalcemia. - Vitamin D analogs: may exacerbate calcium overload. - Digitalis glycosides: elevated calcium can increase digitalis toxicity. - Loop diuretics: may alter calcium balance unpredictably.

Moderate Interactions (Monitor Closely): - ACE inhibitors: monitor blood pressure and renal function. - Antacids containing calcium: cumulative calcium load may require dose adjustment. - Calcium channel blockers: observe for additive cardiovascular effects. - Anticonvulsants (e.g., phenytoin): may affect calcium metabolism. - Proton pump inhibitors: potential impact on calcium absorption.