Icalziss

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt / electrolyte presented as a solution for injection for extracorporeal use. It treats hypocalcemia, provides calcium supplementation during extracorporeal procedures, and supports cardiac contractility and vascular tone in acute care patients.

GNH USA supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Icalziss is used to correct calcium deficits and to support cardiovascular function in settings where calcium balance is critical.

- Hypocalcemia: restores extracellular calcium levels to correct low serum calcium. - Citrate anticoagulation reversal during extracorporeal procedures: supplies calcium ions to counteract citrate‑bound calcium. - Acute cardiac and vascular support: enhances myocardial contractility and vascular tone in emergency or intensive care situations.

Adverse reactions may occur following administration of calcium chloride injection.

Common Side Effects: - Injection site pain or irritation. - Redness or swelling at the infusion site. - Nausea or vomiting. - Headache. - Transient hypotension. - Mild hypercalcemia symptoms such as fatigue.

Serious or Rare Side Effects: - Severe hypercalcemia leading to cardiac arrhythmias. - Tissue necrosis if the solution extravasates. - Cardiac arrest. - Severe hypotension. - Anaphylactic or severe allergic reactions. - Pulmonary edema.

Careful assessment and monitoring are required when using Icalziss.

- Renal impairment: monitor serum calcium and renal function closely. - Cardiac disease: use cautiously due to potential effects on contractility and rhythm. - Existing hypercalcemia: avoid or adjust dose to prevent toxicity. - Concomitant anticoagulants: monitor coagulation parameters for unexpected changes. - Pregnancy and lactation: safety not established; weigh benefits against potential risks. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Calcium chloride may interact with several medications, requiring vigilance.

Major Interactions (Avoid): - Digitalis glycosides: increased risk of arrhythmia due to elevated calcium levels. - Bisphosphonates: calcium may reduce the efficacy of bisphosphonate therapy.

Moderate Interactions (Monitor Closely): - Loop diuretics: may increase calcium excretion; monitor serum calcium. - Anticoagulants (e.g., heparin): calcium can influence coagulation; observe clotting times. - Calcium channel blockers: potential attenuation of calcium’s cardiovascular effects; assess hemodynamics.