Icalziss

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt (electrolyte supplement) presented as a sterile solution for extracorporeal use. It is employed to correct low serum calcium levels and to support electrolyte balance during dialysis and other extracorporeal procedures.

GNH USA supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Icalziss is used as an electrolyte replenisher that restores calcium balance in several clinical situations.

- Hypocalcemia: restores serum calcium concentrations in patients with documented low calcium levels. - Calcium supplementation during dialysis: provides calcium ions to maintain safe calcium levels throughout haemodialysis sessions. - Maintenance of electrolyte balance in extracorporeal circuits: stabilises calcium‑dependent processes in circuits such as continuous renal replacement therapy. - Cardiac contractility support in calcium‑deficient states: helps sustain myocardial contractile function when calcium is insufficient.

Adverse reactions may occur with intravenous calcium administration.

Common Side Effects: - Local irritation at the infusion site: redness or discomfort at the catheter entry. - Transient hypotension: temporary drop in blood pressure during rapid infusion. - Nausea or vomiting: gastrointestinal upset following administration. - Flushing or warmth sensation: mild vasodilatory response. - Muscle twitching: brief involuntary muscle activity.

Serious or Rare Side Effects: - Severe hypercalcemia: excessive serum calcium leading to cardiac arrhythmia. - Cardiac arrhythmia: abnormal heart rhythm, potentially life‑threatening. - Vascular calcification: deposition of calcium in blood vessels with prolonged exposure. - Pulmonary edema: fluid accumulation in lungs due to rapid volume shifts. - Anaphylactoid reaction: rare severe allergic‑type response.

Careful assessment and monitoring are required when using Icalziss.

- Renal impairment: monitor serum calcium and adjust infusion rate to avoid accumulation. - Cardiac disease: evaluate cardiac function before administration, especially in patients with arrhythmias. - Hyperparathyroidism: avoid unless calcium supplementation is specifically indicated. - Concomitant vitamin D therapy: assess total calcium load and modify dosing accordingly. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Calcium chloride may interact with several medications, requiring attention to dosing and monitoring.

Major Interactions (Avoid): - Digitalis glycosides: increased risk of digitalis toxicity due to altered calcium levels. - Loop diuretics: may enhance calcium loss, reducing the effectiveness of supplementation. - Bisphosphonates: calcium can bind to bisphosphonates, diminishing their absorption and efficacy.

Moderate Interactions (Monitor Closely): - ACE inhibitors: monitor blood pressure as calcium may influence vascular tone. - Beta‑blockers: observe for bradycardia when calcium alters cardiac conduction. - Antacids containing aluminum or magnesium: may affect calcium balance and require dose adjustment.