Icalziss

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt presented as an aqueous solution for extracorporeal use. It supplies calcium ions to restore extracellular calcium concentrations and supports physiological processes that depend on calcium, such as cardiac contractility and coagulation.

GNH USA supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable logistics and responsive technical support throughout the supply chain.

Icalziss (calcium chloride dihydrate) is used as an electrolyte supplement in clinical settings that require rapid correction of calcium deficits. - Acute hypocalcemia: restores serum calcium levels to prevent neuromuscular and cardiac complications. - Hemodialysis procedures: provides calcium to maintain electrolyte balance during extracorporeal circulation. - Hyperkalemia management: stabilises cardiac membranes by increasing extracellular calcium concentration.

Calcium chloride dihydrate may cause a range of adverse reactions when administered intravenously.

Common Side Effects: - Local irritation or pain at the infusion site. - Transient flushing or a metallic taste. - Mild hypotension due to vasodilation. - Nausea or mild vomiting. - Elevated serum calcium (mild hypercalcaemia).

Serious or Rare Side Effects: - Severe hypercalcaemia leading to cardiac arrhythmias. - Tissue necrosis or calcification if the solution extravasates. - Life‑threatening cardiac arrest in cases of rapid over‑infusion. - Pulmonary edema from fluid overload. - Anaphylactoid reactions, though extremely uncommon.

When using Icalziss, clinicians should observe several safety measures. - Renal impairment: monitor serum calcium and renal function closely. - Cardiac disease: obtain baseline ECG and watch for arrhythmias. - Concomitant digoxin therapy: assess for increased risk of toxicity. - Pregnancy and lactation: use only if the potential benefit justifies the potential risk to the fetus or infant. - Pediatric patients: adjust dosing and monitor calcium levels carefully. - Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Calcium chloride dihydrate can interact with several medications.

Major Interactions (Avoid): - Digitalis glycosides: increased risk of digoxin toxicity. - Calcium channel blockers: additive cardiovascular effects may cause hypotension. - Bisphosphonates: calcium may reduce oral bisphosphonate absorption if given concurrently.

Moderate Interactions (Monitor Closely): - Loop diuretics: may increase urinary calcium loss, requiring closer monitoring. - Vitamin D analogues: combined use can raise the risk of hypercalcaemia. - Magnesium supplements: may alter calcium balance and require serum level checks.