Icalziss

Calcium chloride dihydrate, the active ingredient in Icalziss, is a calcium salt presented as a sterile solution for extracorporeal use. It supplies calcium ions to support physiological processes and correct calcium deficiency in patients receiving intravenous fluids, dialysis or other extracorporeal therapies.

GNH USA supplies Icalziss as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, dialysis centres and pharmacies worldwide, ensuring quality manufacturing, regulatory compliance, and reliable global distribution to meet clinical needs.

Icalziss, a calcium salt electrolyte, is employed in extracorporeal therapy pathways to maintain calcium balance.

- Intravenous calcium supplementation: provides calcium ions in IV solutions to prevent hypocalcemia during fluid therapy. - Dialysis fluid additive: supplies calcium in dialysate to maintain electrolyte equilibrium during renal replacement therapy. - Extracorporeal circuit electrolyte replacement: restores calcium levels in cardiopulmonary bypass or other extracorporeal circulation systems.

Adverse reactions may occur with calcium chloride dihydrate administration.

Common Side Effects: - Local infusion site irritation: redness or discomfort at the injection site. - Transient hypercalcemia: temporary elevation of serum calcium levels. - Hypotension: drop in blood pressure during rapid infusion. - Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects: - Severe hypercalcemia: can lead to cardiac arrhythmia or neuromuscular dysfunction. - Tissue calcification: deposition of calcium in soft tissues. - Allergic reaction or anaphylaxis: rare but potentially life‑threatening hypersensitivity.

When using Icalziss, consider the following safety measures.

- Renal impairment: monitor serum calcium and adjust dose accordingly. - Cardiac disease: avoid rapid infusion rates to prevent arrhythmias. - Existing hypercalcemia: contraindicated, do not administer. - Concurrent calcium supplements: assess total calcium load to avoid excess. - Electrolyte monitoring: perform regular laboratory checks of calcium, magnesium, and phosphate. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Calcium chloride dihydrate may interact with other agents affecting calcium balance.

Major Interactions (Avoid): - Loop diuretics: increase renal calcium loss, risking hypocalcemia. - Vitamin D analogues (calcitriol): may precipitate severe hypercalcemia. - Bisphosphonates: can lower calcium levels, requiring careful monitoring.

Moderate Interactions (Monitor Closely): - Magnesium sulfate: alters calcium homeostasis, necessitate electrolyte checks. - Warfarin or other anticoagulants: calcium may affect clotting factor activity. - Other electrolytes (potassium, phosphate): simultaneous shifts require regular lab surveillance.