Ibuvalen

Ibuprofen, the active ingredient in Ibuvalen, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats mild to moderate pain, fever and inflammatory conditions in adults and children as directed by a healthcare professional.

GNH USA supplies Ibuvalen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen, an NSAID, reduces pain and inflammation by inhibiting prostaglandin synthesis.

- Headache: relief of mild to moderate headache symptoms. - Dental pain: alleviation of pain following dental procedures. - Musculoskeletal pain: reduction of discomfort from strains, sprains and arthritis. - Fever: lowering of elevated body temperature. - Dysmenorrhea: easing of menstrual cramps and associated pain.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort. - Heartburn: burning sensation in the chest or throat. - Dizziness: feeling light‑headed or unsteady. - Rash: mild skin irritation or itching. - Headache: new or worsening head pain. - Diarrhea: loose stools or increased bowel movements.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulcer perforation. - Renal impairment or acute kidney injury. - Severe allergic reactions such as anaphylaxis. - Liver enzyme elevation or hepatitis. - Cardiovascular thrombotic events including heart attack or stroke. - Blood disorders like thrombocytopenia.

Before using Ibuvalen, consider the following precautions: - Assess renal function: monitor in patients with kidney disease. - Avoid in active ulcer disease: risk of gastrointestinal bleeding. - Use with caution in asthma: may exacerbate bronchospasm. - Limit use in cardiovascular disease: increased risk of thrombotic events. - Avoid in pregnancy third trimester: potential fetal harm. - Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Ibuprofen can interact with several medicines; awareness helps minimize risk.

Major Interactions (Avoid): - Aspirin: increased risk of gastrointestinal bleeding. - Anticoagulants (warfarin, DOACs): heightened bleeding tendency. - Selective COX‑2 inhibitors: additive renal toxicity. - Lithium: elevated lithium serum concentrations. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors: may diminish renal function. - Diuretics: potential for renal impairment. - Corticosteroids: increased risk of gastrointestinal ulceration. - SSRIs: elevated bleeding risk. - Alcohol: enhances gastrointestinal irritation and bleeding potential.