Ibuprofen/Paracetamol Hexal (Ibuprofen, Paracetamol)

Ibuprofen and Paracetamol, the active ingredients in Ibuprofen/Paracetamol Hexal, are a non‑steroidal anti‑inflammatory drug and an analgesic/antipyretic presented as oral tablets for oral use. They are combined to provide relief from pain and fever in adults and children when appropriate. GNH USA supplies Ibuprofen/Paracetamol Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen/Paracetamol Hexal works on inflammatory and pain pathways to reduce discomfort and lower temperature. - Headache: provides rapid relief of tension‑type or mild migraine pain. - Fever: lowers elevated body temperature associated with viral or bacterial infections. - Musculoskeletal pain: eases aches from strains, sprains, osteoarthritis or back pain. - Dental pain: reduces pain after dental procedures or toothache. - Post‑operative pain: helps control mild to moderate pain after minor surgery.

Common Side Effects: - Gastrointestinal discomfort: mild stomach pain, dyspepsia or heartburn. - Nausea or vomiting: occasional upset stomach after ingestion. - Dizziness or light‑headedness: transient sensation of imbalance. - Skin rash: mild erythema or itching at the site of contact.

Serious or Rare Side Effects: - Hepatic injury: signs of liver dysfunction such as jaundice. - Severe allergic reaction: swelling of face, lips, or throat, difficulty breathing. - Gastrointestinal bleeding or ulceration: black stools or vomiting blood. - Renal impairment: reduced urine output or swelling of limbs. - Stevens‑Johnson syndrome or toxic epidermal necrolysis: widespread skin blistering.

Before using Ibuprofen/Paracetamol Hexal, consider the following precautions. - Liver function assessment: evaluate hepatic health, especially with chronic use. - Renal function assessment: monitor kidney status in patients with existing impairment. - Hypersensitivity: avoid if known allergy to ibuprofen, paracetamol, or other NSAIDs. - Alcohol consumption: limit intake as combined use may increase liver risk. - Elderly patients: use lower doses and monitor for adverse effects. - Pregnancy (third trimester): avoid due to potential fetal risks. - Store at ambient temperature: keep in the original pack, protect from moisture.

Ibuprofen/Paracetamol Hexal may interact with other medicines. Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity. - High‑dose paracetamol products: risk of hepatic overload. - Lithium: ibuprofen may raise lithium serum levels. - Methotrexate: ibuprofen can reduce clearance, raising toxicity.

Moderate Interactions (Monitor Closely):\n- Antihypertensives (e.g., ACE inhibitors, ARBs): possible reduction in blood pressure control. - Diuretics: may worsen renal function when combined. - Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding tendency. - Alcohol: additive liver stress. - CYP2C9 substrates (e.g., phenytoin): ibuprofen may alter metabolism.