Ibuprofen

Ibuprofen, the active ingredient in Ibuprofen, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a tablet for oral use. It relieves mild to moderate pain, reduces fever, and eases inflammation in adults and children when appropriate.

GNH USA supplies Ibuprofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts on inflammatory pathways to provide analgesic, antipyretic and anti‑inflammatory benefits. - Mild to moderate pain: provides relief for headaches, dental pain, menstrual cramps and musculoskeletal discomfort. - Fever: lowers elevated body temperature associated with infections or inflammatory conditions. - Osteoarthritis: reduces joint pain and improves mobility in chronic degenerative joint disease. - Rheumatoid arthritis: helps control pain and swelling in autoimmune joint inflammation.

Adverse reactions may range from mild to serious, depending on individual susceptibility and duration of therapy.

Common Side Effects: - Nausea or upset stomach - Heartburn or dyspepsia - Dizziness or light‑headedness - Headache - Mild skin rash - Diarrhoea

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration - Severe allergic reactions (anaphylaxis, angio‑edema) - Acute kidney injury or worsening of chronic renal disease - Liver enzyme elevation or hepatitis - Cardiovascular events such as myocardial infarction or stroke - Blood dyscrasias (e.g., thrombocytopenia).

Before using ibuprofen, consider the following safety measures. - Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use. - Monitor renal function: avoid in patients with severe kidney disease. - Avoid in known hypersensitivity: discontinue if allergic reaction occurs. - Use lowest effective dose: limit duration to reduce adverse events. - Pregnancy and lactation: consult a healthcare professional before use. - Store at ambient temperature: keep below 25°C in the original pack, protect from moisture.

Ibuprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential. - Corticosteroids: additive ulcer risk. - Lithium: reduced renal clearance, possible toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may impair renal function. - Diuretics: risk of reduced kidney perfusion. - Methotrexate: decreased clearance leading to toxicity.