Ibuprofen

Ibuprofen, the active ingredient in Ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an unspecified strength/tablet for oral use. It treats pain, fever and inflammation in adults and children when appropriate.

GNH USA supplies Ibuprofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ibuprofen acts on inflammatory pathways to relieve symptoms across several common conditions.

Pain: provides relief from mild to moderate pain such as headache, dental discomfort, or musculoskeletal aches. Fever: reduces elevated body temperature associated with infections or inflammatory states. Inflammation: diminishes swelling and redness in soft tissues. Arthritis: alleviates joint pain and stiffness in osteoarthritis and rheumatoid arthritis.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Nausea or upset stomach - Dyspepsia or heartburn - Headache - Dizziness - Mild rash or itching - Elevated blood pressure

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration - Severe allergic reactions (anaphylaxis, angioedema) - Renal impairment or failure - Hepatic enzyme elevation - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Cardiovascular events such as myocardial infarction

Before using ibuprofen, consider the following safety measures.

Assess renal function: ensure adequate kidney function, especially in the elderly. Avoid in known hypersensitivity: discontinue if allergic reactions occur. Use lowest effective dose: limit exposure to reduce risk of adverse events. Monitor for gastrointestinal bleeding: watch for black stools or abdominal pain. Avoid concomitant anticoagulants unless advised: increased bleeding risk. Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Ibuprofen can affect the activity of several other medicines.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk. - Lithium: ibuprofen may raise lithium serum concentrations.

Moderate Interactions (Monitor Closely): - Corticosteroids: additive risk of gastric irritation and ulceration. - Methotrexate: reduced clearance may lead to toxicity.