Ibuprofen B. Braun

Ibuprofen, the active ingredient in Ibuprofen B. Braun, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an intravenous solution for intravenous use. It treats pain, fever and inflammation in adult patients.

GNH USA supplies Ibuprofen B. Braun as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Ibuprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

- Pain: provides analgesia for mild to moderate acute or postoperative pain. - Fever: lowers elevated body temperature associated with infectious or inflammatory processes. - Inflammation: decreases swelling and discomfort in conditions such as musculoskeletal injuries or postoperative inflammation.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Dyspepsia: discomfort or burning in the upper abdomen. - Headache: transient head pain. - Dizziness: feeling light‑headed or unsteady. - Injection site reactions: erythema, pain or swelling at the IV site.

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulcer perforation. - Acute renal impairment or failure. - Anaphylactic or severe allergic reactions. - Severe skin reactions such as Stevens‑Johnson syndrome. - Hepatic dysfunction with elevated liver enzymes. - Cardiovascular events including myocardial infarction or stroke in high‑risk patients.

Before initiating therapy, consider patient‑specific risk factors and monitor appropriately. - Renal function: assess baseline creatinine and adjust use in renal impairment. - Hepatic function: monitor liver enzymes in patients with liver disease. - Cardiovascular risk: use caution in patients with known heart disease or hypertension. - Gastrointestinal ulcer: avoid in individuals with active peptic ulcer disease. - Bleeding risk: evaluate concomitant anticoagulant or antiplatelet therapy. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Ibuprofen may interact with several drug classes; clinical judgment is required.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Antiplatelet agents (e.g., clopidogrel): additive antithrombotic effect. - Other NSAIDs: heightened gastrointestinal toxicity. - ACE inhibitors or ARBs: may reduce renal perfusion. - Lithium: ibuprofen can raise lithium serum levels.

Moderate Interactions (Monitor Closely): - Diuretics: possible reduction in antihypertensive efficacy. - Methotrexate: decreased clearance leading to toxicity. - Corticosteroids: synergistic risk of GI ulceration. - SSRIs: modest increase in bleeding tendency. - Beta‑blockers: potential attenuation of antihypertensive response.