Ibu 400 - 1 A Pharma

Ibuprofen, the active ingredient in Ibu 400, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a 400 mg oral tablet for systemic use. It provides analgesic, antipyretic and anti‑inflammatory effects, helping to manage mild to moderate pain, fever and inflammatory conditions in adults and, when appropriate, pediatric patients.

GNH USA supplies Ibu 400 as a licensed, GDP‑compliant international pharmaceutical supplier, delivering the product to hospitals, pharmacies and clinics worldwide in accordance with EU quality standards and regulatory requirements, and ensuring consistent supply chain integrity.

Ibuprofen acts by inhibiting cyclooxygenase enzymes, reducing prostaglandin‑mediated inflammation and pain.

- Mild to moderate pain: Provides analgesic relief for conditions such as backache, menstrual cramps, or minor injuries. - Fever: Reduces elevated body temperature associated with infectious or inflammatory processes. - Headache: Alleviates tension‑type and mild migraine‑related headaches. - Dental pain: Controls postoperative or dental procedural discomfort. - Musculoskeletal pain: Decreases inflammation and soreness in joints, muscles and soft tissues.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort. - Heartburn or acid reflux. - Dizziness or mild vertigo. - Headache. - Skin rash or mild itching. - Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulcer perforation. - Severe renal impairment or acute kidney injury. - Anaphylactic or severe allergic reactions. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatotoxicity with marked liver enzyme elevation. - Hematologic abnormalities such as thrombocytopenia.

Before using ibuprofen, consider the following precautions: - Assess gastrointestinal risk: evaluate history of ulcers or bleeding. - Review renal function: avoid in patients with severe kidney disease. - Monitor cardiovascular status: use cautiously in patients with hypertension or heart disease. - Check for drug allergies: avoid if known hypersensitivity to ibuprofen or other NSAIDs. - Avoid use in late pregnancy unless directed by a physician. - Store at room temperature: keep in the original pack, protect from moisture and heat.

Ibuprofen can interact with several medicines. Review the following categories:

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Corticosteroids: synergistic ulcerogenic effect. - Lithium: elevated lithium serum levels. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: may impair renal perfusion. - Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency. - Antihypertensives: potential attenuation of blood‑pressure‑lowering effect. - Alcohol: additive gastrointestinal irritation.