Ibis

Bilastine, the active ingredient in Ibis, is a H1‑receptor antagonist presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents.

GNH USA supplies Ibis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Bilastine acts on peripheral H1 receptors to relieve allergic symptoms. It is indicated for the following conditions: - Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge. - Chronic idiopathic urticaria: alleviates hives and associated itching. - Seasonal allergic conjunctivitis: helps control eye itching and redness.

Bilastine is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Headache: mild to moderate pain often reported. - Drowsiness: occasional sleepiness, less frequent than with first‑generation antihistamines. - Dry mouth: reduced salivation leading to mild discomfort. - Fatigue: feeling of reduced energy. - Nausea: transient stomach upset.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips or throat requiring urgent care. - Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Anaphylaxis: rare systemic allergic reaction with respiratory or circulatory collapse. - Cardiac arrhythmia: extremely rare but reported in susceptible individuals. - Hepatic injury: isolated cases of liver enzyme elevation.

Before using Bilastine, consider the following safety measures: - Renal impairment: dose adjustment may be required in patients with reduced kidney function. - Hepatic impairment: use with caution in moderate liver disease. - Fruit juice interaction: avoid consuming apple, orange or grapefruit juice within one hour of the dose as it may lower absorption. - Pediatric use: not recommended for children under 12 years unless specifically authorized. - Pregnancy and breastfeeding: safety has not been established; consult a healthcare professional. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Bilastine may interact with other medicines; awareness of the following categories is important.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase Bilastine plasma levels. - Fruit juices (apple, orange, grapefruit): significantly reduce oral absorption. - Concurrent antihistamines: additive sedation or reduced efficacy.

Moderate Interactions (Monitor Closely): - Alcohol: can enhance drowsiness. - Antacids containing aluminum or magnesium: may decrease drug absorption. - QT‑prolonging agents (e.g., certain macrolide antibiotics): monitor cardiac rhythm in at‑risk patients.