Ibifen

Ketoprofen, the active ingredient in Ibifen, is a nonsteroidal anti-inflammatory drug presented as an injectable solution for intramuscular use. It treats pain, inflammation and musculoskeletal disorders in adults, including postoperative pain and rheumatoid arthritis.

GNH USA supplies Ibifen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoprofen is used to manage pain and inflammation associated with several musculoskeletal and postoperative conditions. - Post‑operative pain: provides analgesia and reduces inflammatory response after surgery. - Rheumatoid arthritis: decreases joint inflammation and pain, improving mobility. - Musculoskeletal disorders: relieves pain and swelling in conditions such as sprains, strains and osteoarthritis. - Acute low back pain: reduces pain intensity and improves functional ability. - Dental pain: alleviates pain and inflammation following dental procedures.

Ketoprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Injection site reactions: erythema, swelling or pain at the intramuscular site.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding: potentially life‑threatening hemorrhage. - Renal impairment: acute kidney injury or worsening of chronic kidney disease. - Severe hypersensitivity: anaphylaxis, angioedema or Stevens‑Johnson syndrome.

When prescribing ketoprofen injectable, clinicians should consider several precautionary measures to minimise risk. - Assess renal function: avoid use in patients with severe renal impairment. - Evaluate gastrointestinal risk: use with caution in those with history of ulcers or bleeding. - Monitor hepatic status: avoid in patients with active liver disease. - Use cautiously in elderly: increased susceptibility to adverse effects. - Avoid concomitant use with other NSAIDs or anticoagulants unless medically justified. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Ketoprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity. - Corticosteroids: synergistic risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal function. - Diuretics: potential for decreased diuretic effect and renal impairment. - Lithium: NSAIDs can increase lithium serum levels.