Hypoloc-Plus

Hydrochlorothiazide and Nebivolol, the active ingredients in Hypoloc-Plus, are a thiazide diuretic and a beta‑blocker presented as an oral tablet for oral use. They are combined to treat hypertension in adult patients who require both volume reduction and cardiac output control.

GNH USA supplies Hypoloc-Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Hypoloc-Plus is indicated for the management of hypertension, acting on blood‑pressure regulation pathways.

- Essential hypertension: lowers systolic and diastolic pressure to reduce cardiovascular risk. - Secondary hypertension: assists in controlling blood pressure when caused by underlying conditions. - General high blood pressure: provides consistent pressure control as part of combination therapy.

Common Side Effects: - Dizziness or light‑headedness - Headache - Increased urination or nocturia - Fatigue or weakness - Dry mouth or mild electrolyte imbalance - Mild gastrointestinal discomfort

Serious or Rare Side Effects: - Severe hypotension or syncope - Significant electrolyte disturbances (e.g., hyponatremia, hypokalemia) - Acute renal impairment or failure - Allergic reactions such as rash, angioedema, or anaphylaxis - Bradycardia or heart block - Pancreatitis (rare)

Before initiating therapy, clinicians should consider the following precautions: - Blood pressure monitoring: ensure adequate control and avoid excessive drops. - Electrolyte assessment: regularly check sodium and potassium levels. - Renal function: evaluate creatinine clearance, especially in patients with existing kidney disease. - Discontinuation: avoid abrupt cessation to prevent rebound hypertension. - Diabetes mellitus: monitor blood glucose as diuretics may affect glycemic control. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Hypoloc-Plus may interact with several medicines; careful review is advised.

Major Interactions (Avoid): - Lithium: increased risk of lithium toxicity. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce diuretic efficacy and impair renal function. - Other antihypertensives (e.g., ACE inhibitors, ARBs): additive blood‑pressure lowering effect leading to hypotension. - Potassium‑sparing agents or supplements: risk of hyperkalemia. - MAO inhibitors: potential for severe hypertension.

Moderate Interactions (Monitor Closely): - Digoxin: enhanced plasma levels due to electrolyte changes. - Corticosteroids: may counteract diuretic effect. - Alcohol: can increase dizziness and hypotension. - Antidiabetic drugs: possible alteration in glucose control. - Antidepressants (SSRIs): monitor for additive hypotensive effects.