Hypericum

St. John's Wort, the active ingredient in Hypericum, is a herbal presented as a dry extract for oral use. It is used to support mood and may be considered in mild to moderate depression in adults.

GNH USA supplies Hypericum as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Hypericum (St. John's Wort) is used as an herbal antidepressant acting on monoamine neurotransmission.

Depression: helps improve mood and reduce depressive symptoms in mild to moderate cases. Seasonal affective disorder: may alleviate mood changes associated with seasonal variation.

Hypericum may cause a range of adverse reactions.

Common Side Effects: - Photosensitivity: increased skin sensitivity to sunlight. - Gastrointestinal upset: nausea, stomach discomfort, or diarrhea. - Fatigue or dizziness: feelings of tiredness or light‑headedness. - Headache: mild to moderate head pain.

Serious or Rare Side Effects: - Serotonin syndrome: potentially life‑threatening condition when combined with other serotonergic agents. - Severe allergic reactions: rash, itching, or swelling. - Liver toxicity: abnormal liver function tests or hepatitis. - Mania or hypomania: activation of mood elevation in susceptible individuals.

When using Hypericum, consider the following precautions.

Avoid sun exposure: increased risk of photosensitivity reactions. Monitor mood changes: possible activation of mania or hypomania. Do not combine with serotonergic drugs: risk of serotonin syndrome. Use caution in hepatic impairment: metabolism may be altered. Store at ambient temperature: keep in the original container, protect from moisture and light.

Hypericum interacts with several medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid): - SSRIs (e.g., fluoxetine, sertraline): risk of serotonin syndrome. - MAO inhibitors (e.g., phenelzine): heightened serotonergic activity. - Tricyclic antidepressants (e.g., amitriptyline): increased plasma levels. - Anticoagulants (e.g., warfarin): enhanced anticoagulant effect. - Oral contraceptives: reduced efficacy leading to unintended pregnancy.

Moderate Interactions (Monitor Closely): - Antiepileptics (e.g., phenytoin): decreased drug concentrations. - Immunosuppressants (e.g., cyclosporine): altered metabolism and reduced effectiveness.