GNH USA

Europe — EMA

Ko-Ирбесан

GNH USA supplies Ko-Ирбесан (Hydrochlorothiazide/Irbesartan), a thiazide diuretic and angiotensin II receptor blocker for hypertension.

Hydrochlorothiazide, Irbesartan

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What is Hydrochlorothiazide, Irbesartan?

Hydrochlorothiazide and Irbesartan, the active ingredients in Ko-Ирбесан, are a thiazide diuretic and an angiotensin II receptor blocker presented as tablets for oral use. The combination is indicated for the management of hypertension in adult patients.

GNH USA supplies Ko-Ирбесан as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Hydrochlorothiazide, Irbesartan used for?

Ko-Ирбесан, a combined thiazide diuretic and angiotensin II receptor blocker, is used to treat conditions related to elevated blood pressure.

- Essential hypertension: reduces systolic and diastolic blood pressure. - Secondary hypertension: assists in blood‑pressure control when an underlying cause is identified. - Hypertension in patients with type 2 diabetes: provides additive BP lowering while supporting renal protection.

What are the side effects of Hydrochlorothiazide, Irbesartan?

Common Side Effects: - Dizziness or light‑headedness. - Headache. - Increased urination. - Fatigue. - Electrolyte imbalance (e.g., low potassium). - Mild gastrointestinal upset.

Serious or Rare Side Effects: - Severe dehydration. - Significant electrolyte disturbances such as hyperkalemia or hyponatremia. - Angioedema or severe allergic reaction. - Acute renal impairment. - Hepatic dysfunction. - Life‑threatening hypotension.

What precautions apply to Hydrochlorothiazide, Irbesartan?

Ko-Ирбесан should be used with clinical monitoring and patient education. - Monitor blood pressure: adjust therapy based on response. - Check electrolytes: especially potassium and sodium levels regularly. - Assess renal function: evaluate before initiation and during treatment. - Use with caution in severe hepatic impairment: dose may need adjustment. - Pregnancy and lactation: safety not established; consult a physician. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

What does Hydrochlorothiazide, Irbesartan interact with?

Ko-Ирбесан may interact with several medicines; clinicians should review patient medication lists.

Major Interactions (Avoid): - Potassium‑sparing diuretics: risk of hyperkalemia. - Lithium: increased lithium serum concentrations. - NSAIDs: may blunt antihypertensive effect.

Moderate Interactions (Monitor Closely): - ACE inhibitors or other ARBs: additive blood‑pressure lowering. - Beta‑blockers: may enhance hypotensive response. - Antidiabetic agents: may require dose adjustment due to improved glycemic control.

Frequently asked questions

What is Ko-Ирбесан used for?+
Ko-Ирбесан is a fixed‑dose combination of hydrochlorothiazide and irbesartan indicated for the treatment of hypertension in adult patients. The two agents work together to lower blood pressure by reducing fluid volume and relaxing blood vessels, providing an effective option for patients who need more than one mechanism of action.
How does Hydrochlorothiazide/Irbesartan work?+
Hydrochlorothiazide inhibits sodium and chloride reabsorption in the distal convoluted tubule, promoting diuresis and decreasing plasma volume. Irbesartan blocks AT1 receptors for angiotensin II, preventing vasoconstriction and aldosterone release. The combined effect reduces both vascular resistance and fluid overload, resulting in a greater overall drop in arterial pressure.
What is the usual dose of Ko-Ирбесан?+
The appropriate dose of Ko-Ирбесан is determined by the prescribing healthcare professional based on the individual’s blood‑pressure goals, renal function, and concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.
Is Ko-Ирбесан safe during pregnancy or breastfeeding?+
Safety of the combination in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.
How do I order Ko-Ирбесан from GNH USA?+
To order Ko-Ирбесан, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Ko-Ирбесан compare with other antihypertensive options?+
Compared with monotherapy agents, the hydrochlorothiazide/irbesartan combination offers additive blood‑pressure reduction, often achieving target levels with a single pill. This can improve adherence versus taking two separate drugs. It is particularly useful when patients need both volume reduction and renin‑angiotensin system blockade.
What are the storage and handling requirements for Ko-Ирбесан?+
Ko-Ирбесан tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date printed on the packaging.
How is Ko-Ирбесан administered?+
Ko-Ирбесан is taken orally, usually once daily, with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their prescriber to ensure consistent absorption.
What are the most serious risks to watch for while taking Ko-Ирбесан?+
Serious adverse events include severe dehydration, significant electrolyte disturbances (especially hyperkalemia or hyponatremia), angioedema, acute renal impairment, and life‑threatening hypotension. Patients should seek immediate medical attention if they experience swelling of the face or throat, rapid weight loss, dizziness, or marked changes in urine output.
Who should not use Ko-Ирбесан?+
Ko-Ирбесан is contraindicated in patients with known hypersensitivity to either component, severe renal or hepatic impairment, and in those who are pregnant unless the benefits outweigh the risks. It should also be avoided in individuals taking other potassium‑sparing agents without close monitoring.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Hydrochlorothiazide, Irbesartan
Route
Oral Use
Manufacturer
Nobel Pharma Co., Ltd.
Origin
EU

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