Irbesartán/Hidroclorotiazida Sun

Irbesartan/Hydrochlorothiazide, the active ingredients in Irbesartán/Hidroclorotiazida Sun, are an Angiotensin II receptor blocker and a thiazide diuretic presented as tablets for oral use. They treat hypertension by combining vasodilation and diuretic mechanisms to lower blood pressure in adults. GNH USA supplies Irbesartán/Hidroclorotiazida Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is used in the management of hypertension, a condition characterized by elevated arterial pressure.

Hypertension: lowers systolic and diastolic blood pressure, helping to reduce cardiovascular risk.

Like all medicines, Irbesartan/Hydrochlorothiazide may cause unwanted reactions.

Common Side Effects: - Dizziness or light‑headedness - Headache - Fatigue or weakness - Increased urination - Mild nausea or abdominal discomfort - Electrolyte changes such as low potassium

Serious or Rare Side Effects: - Angioedema (swelling of face, lips, tongue) - Severe dehydration or electrolyte imbalance - Acute kidney injury or worsening renal function - Hyperkalemia (high potassium levels) - Marked hypotension (very low blood pressure) - Severe allergic skin reactions (e.g., Stevens‑Johnson syndrome)

Before prescribing Irbesartan/Hydrochlorothiazide, clinicians should consider the following precautions. - Renal function: assess baseline kidney function and monitor creatinine levels - Electrolytes: regularly check serum potassium and sodium concentrations - Pregnancy: avoid use because of potential fetal harm - Concomitant NSAIDs: may reduce antihypertensive efficacy and affect renal function - Gout: thiazide component can increase serum uric acid - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Irbesartan/Hydrochlorothiazide can interact with several other medicines.

Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: risk of hyperkalemia - Lithium: increased lithium levels and potential toxicity - ACE inhibitors or other ARBs combined: additive renal effects - Aliskiren in diabetic patients: heightened risk of renal impairment - Strong CYP2C9 inhibitors (e.g., fluconazole): may raise irbesartan concentrations

Moderate Interactions (Monitor Closely): - NSAIDs: may blunt the antihypertensive response - Additional thiazide diuretics: additive electrolyte disturbances - Antidiabetic agents: blood glucose may fall, requiring dose adjustment - Beta‑blockers: may enhance blood‑pressure lowering effect - Antacids containing aluminum or magnesium: may affect drug absorption