Irbesartán/Hidroclorotiazida Stada

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartán/Hidroclorotiazida Stada, is an Angiotensin II receptor blocker and thiazide diuretic presented as an oral tablet for oral use. It is indicated for the treatment of hypertension in adult patients.

GNH USA supplies Irbesartán/Hidroclorotiazida Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is used to manage blood‑pressure disorders within the hypertension therapeutic area.

- Essential hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk. - Isolated systolic hypertension: provides effective control of elevated systolic pressure. - Isolated diastolic hypertension: helps achieve target diastolic values.

Adverse reactions may occur with any antihypertensive regimen.

Common Side Effects: - Dizziness or light‑headedness. - Headache. - Fatigue. - Increased urination. - Electrolyte disturbances (e.g., low potassium). - Mild gastrointestinal upset.

Serious or Rare Side Effects: - Severe hypotension. - Acute kidney injury. - Hyperkalemia. - Angioedema. - Severe electrolyte imbalance (e.g., hyponatremia). - Pancreatitis.

Patients should be evaluated for renal function, electrolyte status, and cardiovascular health before initiating therapy.

- Renal impairment: monitor serum creatinine and adjust dose if needed. - Electrolyte imbalance: check potassium and sodium levels regularly. - Diabetes mellitus: watch for changes in blood glucose control. - Pregnancy: avoid use unless benefits outweigh potential risks. - Concomitant NSAIDs: increase risk of renal dysfunction. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Irbesartan/Hydrochlorothiazide may interact with several drug classes, requiring clinical awareness.

Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: risk of hyperkalemia. - Lithium: increased lithium levels and toxicity. - ACE inhibitors or other ARBs: additive hypotensive effect.

Moderate Interactions (Monitor Closely): - NSAIDs: may reduce antihypertensive efficacy and impair renal function. - Antidiabetic agents: possible alteration of glucose control. - Antimicrobials (e.g., trimethoprim): may affect potassium balance.