Irbesartán/Hidroclorotiazida Almus

Irbesartan/Hydrochlorothiazide, the active ingredient in Irbesartán/Hidroclorotiazida Almus, is an angiotensin II receptor blocker / thiazide diuretic presented as a tablet for oral use. It treats hypertension in adult patients. GNH USA supplies Irbesartán/Hidroclorotiazida Almus as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Irbesartan/Hydrochlorothiazide is used in the management of hypertension, targeting the renin‑angiotensin system and renal sodium handling.

Hypertension: reduces systolic and diastolic blood pressure in adults. Resistant hypertension: provides additional control when monotherapy is insufficient. Hypertension with edema: promotes diuresis to help manage fluid overload associated with high blood pressure.

Common Side Effects: - Dizziness or light‑headedness. - Headache. - Increased urination. - Mild electrolyte disturbances (e.g., low potassium). - Fatigue. - Gastrointestinal discomfort.

Serious or Rare Side Effects: - Angioedema or severe allergic reaction. - Hyperkalemia or severe electrolyte imbalance. - Acute kidney injury. - Severe dehydration. - Hepatic injury. - Blood dyscrasias such as agranulocytosis.

Before initiating therapy, consider the following precautions: - Monitor electrolytes: check potassium and sodium levels regularly. - Assess renal function: evaluate serum creatinine and eGFR before and during treatment. - Avoid in severe hepatic impairment: use with caution or consider alternatives. - Pregnancy: contraindicated in the second and third trimesters due to fetal risk. - Drug interactions: review concomitant medications for additive potassium effects. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

Irbesartan/Hydrochlorothiazide may interact with several medicines.

Major Interactions (Avoid): - Potassium‑sparing diuretics: risk of hyperkalemia. - ACE inhibitors or ARBs combined with aliskiren in diabetic patients: increased renal risk. - Lithium: may raise lithium concentrations. - NSAIDs: can diminish antihypertensive effect and affect renal function.

Moderate Interactions (Monitor Closely): - Other antihypertensives: additive blood pressure lowering. - Corticosteroids: may increase potassium loss. - Beta‑blockers: monitor for excessive hypotension.