GNH USA

Europe — EMA

Hyalistil

Learn about Hyalistil sodium hyaluronate ocular lubricant – its uses, mechanism, side effects, precautions, and interactions for eye care professionals.

Sodium Hyaluronate

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What is Sodium Hyaluronate?

Hyalistil is a sodium hyaluronate ophthalmic viscosurgical device marketed in the European Union. It is supplied as a sterile ocular solution designed to provide lubrication to the eye surface. The product contains sodium hyaluronate, a high‑molecular‑weight polymer that mimics natural hyaluronic acid. Hyalistil is intended for use under the supervision of an eye‑care professional. It may be used before or after ocular procedures to support corneal health and patient comfort.

What is Sodium Hyaluronate used for?

Hyalistil is employed as an ocular lubricant and viscoelastic adjunct in various eye‑care situations.

- To provide temporary relief of dryness and irritation associated with environmental factors or contact lens wear. - As a protective coating during intra‑ocular surgeries such as cataract extraction to maintain anterior chamber stability. - To support corneal epithelial healing after minor trauma, abrasions, or surface procedures. - As an adjunct in the management of postoperative inflammation to enhance patient comfort.

What are the side effects of Sodium Hyaluronate?

Adverse reactions to Hyalistil are generally mild, but ocular products can occasionally cause more significant effects.

Common: - Transient stinging or burning sensation upon instillation. - Temporary blurred vision that resolves within minutes. - Mild conjunctival redness or irritation. - Slight increase in tear production.

Serious: - Persistent ocular inflammation or uveitis. - Corneal epithelial defect or ulceration. - Allergic hypersensitivity reaction presenting as swelling, itching, or rash. - Severe pain or vision loss requiring immediate medical attention.

What precautions apply to Sodium Hyaluronate?

When considering Hyalistil, clinicians should evaluate patient history and ocular condition to minimize risk.

- Avoid use in patients with known hypersensitivity to sodium hyaluronate or any formulation components. - Do not administer if the ocular surface is infected or inflamed until the condition is treated. - Use caution in eyes that have undergone recent surgery; monitor for delayed healing. - Contact lens wearers should remove lenses before instillation and wait before reinserting. - Store the product according to the label, protecting it from light and extreme temperatures. - Discard any vial that appears cloudy, discolored, or past its expiration date.

What does Sodium Hyaluronate interact with?

Hyalistil may interact with other ophthalmic agents, influencing efficacy or safety.

Avoid: - Simultaneous use with preservative‑containing eye drops that may increase ocular surface toxicity. - Co‑administration with other viscoelastic devices during the same surgical procedure, which could lead to excessive intra‑ocular pressure.

Use with caution: - Topical corticosteroids; monitor for delayed wound healing. - Antihistamine eye drops; assess for additive drying effect. - Systemic medications that affect wound healing, such as chemotherapy agents, when surgery is planned.

Frequently asked questions

What is the active ingredient in Hyalistil and how does it differ from regular hyaluronic acid?+
The active ingredient is sodium hyaluronate, the sodium salt of hyaluronic acid. It is a high‑molecular‑weight polymer formulated for ophthalmic use, providing greater viscosity and stability on the ocular surface compared with standard hyaluronic acid solutions.
How is Hyalistil administered during eye surgery?+
During surgery, a sterile drop or injection of Hyalistil is placed onto the ocular surface or into the anterior chamber to create a viscoelastic layer that protects tissues and maintains space for instrument manipulation.
Can Hyalistil be used for dry eye syndrome?+
Yes, Hyalistil can be used as an ocular lubricant to temporarily relieve dryness and irritation associated with dry eye, although it is often selected for short‑term or peri‑operative use.
What are the storage requirements for Hyalistil?+
The product should be stored at room temperature, protected from direct light and extreme temperatures. It must be kept in its original container and discarded after the expiration date or if the solution becomes cloudy.
How long does the lubricating effect of Hyalistil typically last after instillation?+
The lubricating film generally persists for several minutes to an hour, depending on tear film dynamics and environmental conditions. Re‑application may be needed for prolonged relief.
Is Hyalistil available over the counter in the EU?+
In most EU member states, Hyalistil is classified as a prescription‑only product and must be obtained through a qualified eye‑care professional.
What signs indicate an allergic reaction to Hyalistil?+
Signs of an allergic reaction include swelling, itching, redness, rash around the eye, or worsening discomfort that does not resolve quickly after application.
Can Hyalistil be used together with contact lenses?+
Contact lenses should be removed before instilling Hyalistil. After the solution is absorbed (usually a few minutes), lenses can be re‑inserted if needed.
What precautions should be taken for patients with recent ocular surgery?+
Patients who have had recent surgery should be monitored for delayed healing, intra‑ocular pressure changes, and signs of infection. Hyalistil should be used only under the surgeon’s guidance.
How does Hyalistil compare to other ocular lubricants in terms of viscoelastic properties?+
Hyalistil’s sodium hyaluronate formulation provides a higher viscosity and longer residence time on the ocular surface than many simple artificial tears, making it especially useful in surgical settings and for short‑term protection.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Sodium Hyaluronate
Route
Ocular Use
Manufacturer
Sifi S.P.A.
Origin
EU

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