Hiprex

Hiprex is an oral prescription medication containing the active ingredient methenamine hippurate. It is supplied in tablet form (strength not specified) and marketed in the European Union. The product is classified as a urinary antiseptic and is used under medical supervision to help reduce the risk of urinary tract infections by delivering antibacterial activity within the urinary tract.

Hiprex is indicated for the prophylactic management of urinary tract infections in patients who experience recurrent episodes.

- Prevention of recurrent uncomplicated urinary tract infections in women. - Prophylaxis of urinary tract infections in patients with known risk factors such as catheter use. - Use in individuals with normal acidic urinary pH to ensure drug activation. - Adjunct to non‑pharmacologic measures (hydration, hygiene) for long‑term infection control. - May be considered in patients who have completed an acute treatment course and require ongoing protection.

Like most medications, Hiprex may cause adverse reactions, most of which are mild and reversible.

Common: - Nausea. - Dyspepsia. - Flatulence. - Headache.

Serious: - Severe allergic reaction (anaphylaxis). - Hematuria. - Acute interstitial nephritis.

Before starting Hiprex, several safety considerations should be reviewed.

- Ensure urinary pH is acidic; effectiveness decreases when urine is alkaline. - Not recommended for patients with known hypersensitivity to methenamine or formaldehyde. - Use with caution in individuals with renal impairment or reduced kidney function. - Avoid in patients with severe liver disease that may affect drug metabolism. - Monitor for signs of allergic reaction during initial therapy. - Pregnant or breastfeeding women should consult a healthcare professional before use.

Hiprex can interact with other agents that affect urinary pH or renal function.

Avoid: - Alkalinizing agents (e.g., potassium citrate, sodium bicarbonate) that raise urinary pH and reduce drug activation. - Concurrent use of strong acids that may cause urinary irritation.

Use with caution: - Anticoagulants (warfarin) as formaldehyde may affect clotting parameters. - Other urinary antiseptics or antibiotics, which could alter the overall antimicrobial effect. - Diuretics that increase urine output, potentially affecting drug concentration.