GNH USA

Europe — EMA

Hidrocloruro De Fenilefrina Altan 10 Mg/Ml

Learn about Hidrocloruro De Fenilefrina Altan 10 mg/mL, its uses, mechanism, side effects, precautions, and drug interactions for phenylephrine hydrochloride.

Phenylephrine Hydrochloride

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What is Phenylephrine Hydrochloride?

Hidrocloruro De Fenilefrina Altan 10 mg/mL is a phenylephrine hydrochloride solution intended for parenteral administration. The product contains 10 mg of phenylephrine per milliliter and is supplied as an injectable preparation for intramuscular, intravenous, or subcutaneous use. It is marketed in the European Union and requires a prescription.

What is Phenylephrine Hydrochloride used for?

Hidrocloruro De Fenilefrina Altan is employed in clinical settings where rapid vasoconstriction is needed. It is commonly used for: - Treatment of acute hypotension, especially during anesthesia or shock. - Relief of nasal congestion caused by allergic or viral rhinitis. - Management of upper airway edema, such as after intubation or surgery. - Adjunct therapy for certain types of bronchial obstruction. - Supportive care in patients with severe allergic reactions where airway swelling is present.

What are the side effects of Phenylephrine Hydrochloride?

Adverse reactions to phenylephrine may vary in frequency and severity.

Common: - Headache - Palpitations or tachycardia - Hypertension or transient blood pressure elevation - Nausea or vomiting - Local irritation at the injection site

Serious: - Severe hypertension with risk of end‑organ damage - Cardiac arrhythmias, including atrial fibrillation - Reflex bradycardia - Ischemic chest pain or myocardial infarction - Cerebral hemorrhage in susceptible individuals

What precautions apply to Phenylephrine Hydrochloride?

Use of phenylephrine requires careful assessment of patient risk factors. Consider the following precautions: - Assess baseline blood pressure; avoid use in uncontrolled hypertension. - Monitor cardiac rhythm in patients with known arrhythmias. - Use cautiously in patients with coronary artery disease or recent myocardial infarction. - Evaluate for hyperthyroidism, as increased catecholamine sensitivity may amplify effects. - Adjust dose or avoid in patients receiving monoamine oxidase inhibitors (MAOIs). - Pregnant or nursing patients should be managed only if benefits outweigh potential risks.

What does Phenylephrine Hydrochloride interact with?

Phenylephrine can interact with several medication classes. Relevant interactions include:

Avoid: - Concurrent use with other potent vasoconstrictors (e.g., norepinephrine, epinephrine) due to additive hypertension risk. - MAO inhibitors, which may potentiate hypertensive responses. - Tricyclic antidepressants that increase norepinephrine levels.

Use with caution: - Beta‑blockers, which may mask tachycardia while allowing blood pressure rise. - Diuretics or antihypertensives, as phenylephrine may counteract their effects. - Lithium, because altered renal perfusion can affect lithium clearance.

Frequently asked questions

What is the primary therapeutic class of Hidrocloruro De Fenilefrina Altan?+
It belongs to the alpha‑1 adrenergic agonist class, a subgroup of sympathomimetic agents that cause vasoconstriction.
Which routes of administration are approved for this phenylephrine product?+
The solution is formulated for intramuscular, intravenous, and subcutaneous injection.
Can Hidrocloruro De Fenilefrina Altan be used to treat nasal congestion?+
Yes, it is indicated for relief of nasal congestion by reducing mucosal edema through vasoconstriction.
Is phenylephrine hydrochloride available over the counter?+
No, this formulation is prescription‑only (Rx) in the European Union.
What should be monitored when administering phenylephrine to a patient with hypertension?+
Blood pressure should be closely monitored, and the drug should be avoided or used with caution in uncontrolled hypertension.
How does phenylephrine differ from epinephrine in its mechanism?+
Phenylephrine selectively stimulates alpha‑1 receptors, whereas epinephrine activates both alpha and beta receptors, producing broader cardiovascular effects.
Are there any specific contraindications for this medication?+
Contraindications include patients with severe hypertension, known hypersensitivity to phenylephrine, and those taking monoamine oxidase inhibitors.
What are common adverse reactions after an intramuscular injection of phenylephrine?+
Common reactions include headache, palpitations, transient hypertension, nausea, and local injection‑site irritation.
Should phenylephrine be used in pregnant women?+
Use only if the potential benefit justifies the potential risk, as safety data in pregnancy are limited.
Can phenylephrine interact with beta‑blocker therapy?+
Yes, beta‑blockers may mask tachycardia while allowing phenylephrine‑induced blood pressure elevation, so combined use requires careful monitoring.
What is the typical concentration of phenylephrine in this product?+
The solution contains 10 mg of phenylephrine hydrochloride per milliliter.
Is there a risk of reflex bradycardia with phenylephrine use?+
Reflex bradycardia can occur as a response to increased blood pressure, especially at higher doses.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Phenylephrine Hydrochloride
Route
Intramuscular Use , Intravenous Use , Subcutaneous
Manufacturer
Altan Pharmaceuticals S.A.
Origin
EU

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