GNH USA

Europe — EMA

Hexaflu Day & Night

Hexaflu Day & Night is an OTC oral combo of diphenhydramine, paracetamol and pseudoephedrine for cold, flu and allergy symptom relief.

Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol

Request sourcing

1
Pack/s

What is Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol?

Hexaflu Day & Night is an over‑the‑counter oral medication that combines diphenhydramine hydrochloride, paracetamol, and pseudoephedrine hydrochloride. It is formulated to provide multi‑symptom relief for cold and flu, including allergy, pain, fever, and nasal congestion. The product is marketed in the European Union and is supplied as an oral tablet. Each tablet combines an antihistamine, an analgesic/antipyretic and a nasal decongestant for convenient day‑and‑night symptom control.

What is Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol used for?

Hexaflu Day & Night is indicated for temporary relief of several common cold, flu and allergy symptoms.

- Relief of nasal congestion and sinus pressure associated with colds or allergic rhinitis. - Reduction of headache, muscle aches, and fever through analgesic and antipyretic action. - Alleviation of sneezing, itchy eyes, and runny nose caused by histamine release. - Support for daytime symptom control when decongestion is needed without excessive sedation. - Nighttime use to manage allergy‑related insomnia and discomfort while maintaining pain relief.

What are the side effects of Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol?

Like many combination cold medicines, Hexaflu Day & Night may cause a range of adverse reactions, most of which are mild and transient.

Common: - Drowsiness or mild sedation, especially from diphenhydramine. - Dry mouth, throat or nasal passages. - Nausea, stomach discomfort or loss of appetite. - Light‑headedness or mild dizziness.

Serious: - Rapid heart rate, palpitations, or high blood pressure. - Severe allergic reactions such as rash, itching, swelling, or difficulty breathing. - Hallucinations or confusion, particularly in older adults. - Persistent vomiting or signs of liver stress.

What precautions apply to Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol?

Before using Hexaflu Day & Night, consider the following precautions to ensure safe and appropriate use.

- Avoid use if you have known hypersensitivity to any component. - Use caution in patients with hypertension, heart disease, diabetes, or thyroid disorders. - Not recommended for children under a specified age without medical advice. - Limit use if you are taking other products containing paracetamol or decongestants to prevent overdose. - Pregnant or breastfeeding individuals should consult a healthcare professional before use. - Alcohol consumption may increase drowsiness and liver strain.

What does Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol interact with?

Hexaflu Day & Night can interact with several medicines; reviewing these interactions helps prevent adverse effects.

Avoid: - Other antihistamines, sedatives, or CNS depressants that may enhance drowsiness. - Additional decongestants or sympathomimetic agents that could raise blood pressure. - Monoamine‑oxidase inhibitors (MAOIs) or recent MAOI therapy.

Use with caution: - Anticoagulants or antiplatelet drugs, due to potential increased bleeding risk with paracetamol. - Certain antidepressants (e.g., SSRIs) that may affect serotonin levels. - Medications metabolized by CYP2D6, as diphenhydramine can inhibit this pathway.

Frequently asked questions

What symptoms does Hexaflu Day & Night treat?+
It is used to temporarily relieve nasal congestion, sinus pressure, headache, fever, muscle aches, sneezing, itchy eyes and runny nose associated with colds, flu and allergic rhinitis.
Can I take Hexaflu Day & Night if I have high blood pressure?+
Use caution and consult a healthcare professional, as pseudoephedrine can raise blood pressure in some individuals.
Is Hexaflu Day & Night safe for pregnant women?+
Pregnant or breastfeeding individuals should speak with a doctor before using this product, because safety data are limited.
How does diphenhydramine in Hexaflu Day & Night work?+
Diphenhydramine blocks H1 histamine receptors, reducing the allergic response that causes itching, sneezing and nasal discharge.
What is the role of paracetamol in this combination?+
Paracetamol provides analgesic and antipyretic effects by inhibiting central cyclooxygenase enzymes, which lowers pain and fever.
Why is pseudoephedrine included in Hexaflu Day & Night?+
Pseudoephedrine acts as an α‑adrenergic agonist, causing vasoconstriction of nasal blood vessels and relieving congestion.
Can I take other cold medicines with Hexaflu Day & Night?+
Avoid other products that contain diphenhydramine, paracetamol, or pseudoephedrine to prevent accidental overdose.
What should I do if I experience severe dizziness after taking Hexaflu Day & Night?+
Stop the medication and seek medical attention, especially if dizziness is accompanied by rapid heartbeat or high blood pressure.
Is alcohol consumption allowed while using Hexaflu Day & Night?+
Alcohol may increase drowsiness and liver strain, so it is best to limit or avoid alcohol while taking the product.
How often can I take Hexaflu Day & Night?+
Follow the dosing instructions on the package or those given by a healthcare professional; do not exceed the recommended maximum daily amount.
Can children use Hexaflu Day & Night?+
The product is not recommended for young children without medical advice; dosage and suitability depend on age and weight.
What are signs of an allergic reaction to Hexaflu Day & Night?+
Symptoms may include rash, itching, swelling of the face or throat, and difficulty breathing; seek emergency care if these occur.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Diphenhydramine Hydrochloride, Paracetamol | Pseudoephedrine Hydrochloride, Paracetamol
Route
Oral Use
Manufacturer
Johnson & Johnson Hellas Consumer Ae
Origin
EU

Related products