Europe — EMA
Hedrin (Dimeticone)
Hedrin 4% dimeticone lotion is an EU‑approved, OTC pediculicide for safe, chemical‑free treatment of head lice infestations.
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What is Dimeticone?
Hedrin is an over‑the‑counter pediculicide lotion containing 4% w/v dimeticone, a silicone‑based compound. It is formulated for cutaneous application to treat head‑lice infestation (pediculosis capitis) and is marketed in the European Union. The product works by physically coating lice, blocking their respiratory spiracles, and causing suffocation without relying on chemical insecticides.
What is Dimeticone used for?
Hedrin is indicated for the topical treatment of head lice infestations in individuals of all ages. It is applied to dry hair and scalp, left in place for the recommended time, then rinsed off.
- Effective against live lice and newly hatched nymphs. - Suitable for use on children older than 6 months and adults. - Can be used as part of an integrated lice‑control program that includes combing. - Does not contain neurotoxic insecticides, reducing risk of resistance. - Provides a non‑chemical alternative for families seeking silicone‑based options.
What are the side effects of Dimeticone?
Side effects reported with Hedrin are generally mild and related to the topical nature of the product.
Common: - Mild scalp irritation or itching. - Transient redness at the application site. - Dryness or flaking of hair. - Temporary tingling sensation.
Serious: - Allergic contact dermatitis (rash, swelling, blistering). - Severe itching or swelling requiring medical evaluation. - Rare systemic reactions such as urticaria. - Persistent irritation beyond 24 hours. - Secondary infection from scratching affected areas.
What precautions apply to Dimeticone?
Before using Hedrin, consider the following safety measures to minimize adverse reactions.
- Perform a patch test on a small skin area 24 hours before full application. - Avoid use on broken, inflamed, or sunburned skin. - Do not apply to eyes, mucous membranes, or open wounds. - Keep the product out of reach of children; store at room temperature. - If pregnancy or breastfeeding status is unknown, consult a healthcare professional before use. - Discontinue use and seek medical advice if signs of an allergic reaction develop.
What does Dimeticone interact with?
Hedrin’s silicone base has limited potential for drug interactions, but certain substances may affect its performance.
Avoid: - Applying other topical medicated shampoos or hair treatments immediately before or after Hedrin. - Use on hair that has been chemically treated (e.g., bleach, perm) without thorough rinsing.
Use with caution: - Concurrent use of scalp moisturizers or oils that may create a barrier over the product. - Application on hair containing heavy styling products that could reduce coating efficacy. - Use in combination with other lice‑control products; follow timing recommendations to avoid overlapping exposure.

