Harmonet

Harmonet is a combined oral contraceptive tablet containing the synthetic estrogen ethinylestradiol and the progestogen gestodene. It is marketed in the European Union as a prescription‑only medication for hormonal contraception. The product is supplied as tablets; specific strength information is not disclosed in this summary. Harmonet works by preventing ovulation and creating cervical and endometrial conditions unfavorable for fertilisation through hormonal regulation of the menstrual cycle.

Harmonet is indicated for the prevention of pregnancy in women of reproductive age who choose an oral hormonal method.

- Primary contraceptive use: regular daily dosing to inhibit ovulation. - Management of menstrual cycle irregularities when combined with contraception. - May be prescribed for acne improvement associated with hormonal imbalance (off‑label in some regions). - Provides cycle control and reduces the risk of ovarian cyst formation. - Can be used as part of a combined hormone regimen after childbirth or abortion, following medical guidance.

Like other combined oral contraceptives, Harmonet may cause a range of side effects that vary in frequency and severity.

Common: - Nausea or mild stomach upset, especially when treatment is initiated. - Breast tenderness or enlargement. - Headache or mild migraine episodes. - Spotting or breakthrough bleeding during the first few cycles. - Weight fluctuations or fluid retention, often mild and transient. - Mood changes, including irritability or mild depressive symptoms.

Serious: - Deep vein thrombosis, pulmonary embolism, or other thromboembolic events. - Severe allergic reaction such as rash, itching, swelling of the face or throat, or difficulty breathing. - Liver dysfunction indicated by jaundice, dark urine, or severe abdominal pain.

Before starting Harmonet, certain health considerations should be reviewed to ensure safe use and to minimise risks.

- History of thromboembolic disorders, such as deep‑vein thrombosis or pulmonary embolism. - Current or past cardiovascular disease, including hypertension, stroke, or myocardial infarction. - Smoking, especially in women over 35 years of age. - Liver disease or impaired liver function. - Migraines with aura or severe headache disorders. - Pregnancy or suspected pregnancy; the product should not be used during pregnancy. - Breastfeeding women should consult a healthcare professional before using Harmonet.

Harmonet can interact with other medicines, which may alter its effectiveness or increase the risk of adverse events.

Avoid: - Anticoagulants such as warfarin, where hormonal contraception may affect clotting parameters. - Certain anticonvulsants (e.g., carbamazepine, phenytoin) that can reduce oral contraceptive efficacy.

Use with caution: - Antibiotics like rifampicin that may lower hormone levels. - Herbal supplements containing St. John’s wort, which can induce hepatic enzymes. - Antiretroviral drugs (e.g., protease inhibitors) that may require monitoring of contraceptive reliability. - SSRIs such as fluoxetine may increase the risk of breakthrough bleeding. - Diuretics may increase the risk of electrolyte imbalance when combined with hormonal contraceptives.