Gynoflor

Gynoflor is a vaginal formulation that combines the estrogen estriol with lyophilized Lactobacillus acidophilus. It is marketed in the European Union for local gynecological hormone therapy. The product delivers a low‑dose estrogen directly to the vaginal tissue while the probiotic component supports a healthy vaginal microbiome, helping to alleviate symptoms associated with estrogen deficiency.

Gynoflor is indicated for the management of estrogen‑related vaginal conditions in post‑menopausal women and others experiencing hormonal changes. It is used to improve vaginal health and comfort.

- Relief of vulvovaginal atrophy symptoms such as dryness and irritation - Reduction of menopausal vaginal symptoms including itching and burning - Support of normal vaginal flora through probiotic action - Adjunctive therapy after menopause‑related estrogen decline - Management of mild to moderate vaginal discomfort associated with low estrogen levels

Side effects of Gynoflor are generally mild and related to local vaginal exposure, but rare serious reactions can occur.

Common: - Mild vaginal irritation or burning sensation - Spotting or light vaginal bleeding - Increased vaginal discharge - Temporary itching or discomfort - Mild abdominal cramping

Serious: - Allergic reaction with swelling, rash, or hives - Severe vaginal bleeding - Persistent pelvic pain - Signs of infection such as fever or foul odor - Unexplained weight gain or swelling

Before using Gynoflor, consider the following precautions to ensure safe and appropriate use.

- Confirm that there is no active vaginal infection or untreated cervical pathology - Use with caution in women with a history of estrogen‑dependent cancers - Discuss use with a healthcare provider if you are pregnant, planning pregnancy, or breastfeeding - Monitor for any unexpected vaginal bleeding or discharge and report to a clinician - Avoid use if you have known hypersensitivity to estriol or Lactobacillus acidophilus - Keep the product out of reach of children and store according to label instructions

Gynoflor may interact with other medications or substances that affect estrogen activity or vaginal health.

Avoid: - Systemic estrogen therapies that could increase overall estrogen exposure - Antifungal or antibacterial vaginal products applied simultaneously, which may reduce probiotic viability

Use with caution: - Hormonal contraceptives containing estrogen - Medications that influence coagulation, such as anticoagulants - Systemic corticosteroids that may affect immune response - Herbal supplements with estrogenic activity (e.g., phytoestrogens) - Any drug that alters vaginal pH or microbiome balance