Gynoflor

Gynoflor is a prescription vaginal tablet that combines the estrogen estriol with the probiotic Lactobacillus acidophilus. Each tablet delivers a low‑dose estriol formulation together with live lactobacilli, designed for local application in the vagina. The product is marketed in the European Union for the treatment of estrogen‑deficiency‑related vaginal atrophy and for restoration of normal vaginal flora. It is intended for use under supervision and is not available over the counter.

Gynoflor is indicated for conditions related to estrogen deficiency in the vaginal tissue and for supporting a healthy microbial environment.

- Treatment of vaginal atrophy caused by menopause or other estrogen‑deficient states. - Relief of dyspareunia (painful intercourse) associated with vaginal dryness. - Management of chronic vaginal dryness and irritation. - Restoration and maintenance of normal Lactobacillus‑dominant vaginal flora. - Adjunct therapy after antibiotic treatment for bacterial vaginosis.

Local application of Gynoflor may produce a range of effects, most of which are mild and resolve without intervention.

Common: - Mild vaginal irritation or burning sensation. - Increased vaginal discharge that is clear or whitish. - Spotting or light vaginal bleeding, especially during initial use. - Temporary increase in urinary frequency.

Serious: - Severe allergic reaction with swelling of the vulva, itching, or rash. - Persistent or heavy vaginal bleeding. - Signs of estrogen‑dependent tumor growth (rare).

Before prescribing Gynoflor, clinicians should evaluate patient history and consider specific safety factors.

- Not recommended for women with known hypersensitivity to estriol or Lactobacillus species. - Caution in patients with a history of estrogen‑dependent cancers (e.g., breast, endometrial). - Use with care in individuals with unexplained vaginal bleeding. - Avoid in active thromboembolic disorders or severe liver disease. - Discuss potential risks with pregnant or breastfeeding women; safety data are limited. - Monitor for signs of infection if used after antibiotic therapy.

Gynoflor can interact with systemic medications or other vaginal products, influencing efficacy or safety.

Avoid: - Concurrent use of systemic estrogen therapy (may increase overall estrogen exposure). - Use with other vaginal hormonal preparations (risk of excess estrogen).

Use with caution: - Antifungal or antibacterial vaginal agents (may affect probiotic viability). - Hormonal contraceptives containing estrogen (monitor for additive effects). - Medications that influence coagulation (e.g., oral anticoagulants) – monitor bleeding risk.