Europe — EMA
Glycerine Enfants Gilbert (Glycerol)
Glycerine Enfants Gilbert is a glycerol‑based rectal solvent used to lubricate and soften stool. Learn its uses, effects, precautions, and interactions.
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What is Glycerol?
Glycerine Enfants Gilbert is a rectal preparation whose sole active ingredient is glycerol (glycerine). The product is supplied in an unspecified strength and form, typical of liquid or suppository preparations used as a solvent and humectant. Marketed within the European Union, it belongs to the excipient class and functions primarily to provide lubrication and moisture to the rectal mucosa. It does not contain additional medicinal agents.
What is Glycerol used for?
Glycerine Enfants Gilbert is employed as a rectal solvent and humectant in clinical and home settings, primarily to facilitate the passage of stool and to protect mucosal tissue.
- Softens hardened fecal material to aid natural evacuation. - Provides a lubricating coating that reduces friction during defecation. - Helps maintain moisture of the rectal lining to prevent irritation. - Can be used as a pre‑procedure enema to clear the bowel. - Supports gentle cleansing when combined with water for rectal irrigation.
What are the side effects of Glycerol?
When applied rectally, glycerol may cause local sensations or reactions; most are mild and transient, while rare events can be more concerning.
Common: - Mild burning or stinging sensation at the application site. - Temporary increase in bowel movement frequency that subsides within a few hours. - Light abdominal cramping or loose stool shortly after use. - Slight watery diarrhea that resolves without medical intervention.
Serious: - Persistent rectal irritation or ulceration that does not improve with discontinuation. - Severe abdominal pain lasting several hours and unresponsive to usual measures. - Signs of allergic reaction such as rash, swelling, or itching around the anal area. - Unexplained rectal bleeding or blood in the stool following administration.
What precautions apply to Glycerol?
Before using Glycerine Enfants Gilbert, consider several safety measures to minimize risk and ensure appropriate application in various populations.
- Avoid use if there is a known allergy to glycerol or related compounds. - Do not apply if rectal bleeding, fissures, or severe hemorrhoids are present. - Use with caution in infants and young children; consult a healthcare professional first. - Limit frequency to avoid excessive moisture that could irritate the mucosa. - Store the product at room temperature away from direct sunlight and moisture. - Keep out of reach of children to prevent accidental ingestion.
What does Glycerol interact with?
Glycerine Enfants Gilbert may interact with other rectal agents or systemic medications; understanding these interactions helps prevent reduced efficacy or adverse effects.
Avoid: - Avoid concurrent use with strong laxatives or stimulant enemas that may cause excessive bowel stimulation. - Avoid mixing with alcohol‑based solutions, as glycerol can enhance absorption and increase systemic exposure.
Use with caution: - Use with caution when combining with other humectants or lubricants, as cumulative moisture may irritate the rectal lining. - Use with caution in patients taking anticoagulants, because rectal irritation could increase bleeding risk. - Use with caution if the patient has diabetes, since glycerol can affect blood glucose levels when absorbed.



