GNH USA

USA — NDC

Dupixent 200 mg/1.14mL

GNH USA supplies Dupixent (Dupilumab), an interleukin-4 receptor alpha antagonist for moderate-to-severe atopic dermatitis, asthma, and chronic

Dupilumab
Dupixent
INJECTION, SOLUTION
200 mg/1.14mL

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1
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What is Dupilumab?

Dupilumab, the active ingredient in Dupixent, is an interleukin-4 receptor alpha antagonist presented as a 200 mg/1.14 mL solution for subcutaneous use. It is used to treat moderate-to-severe atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps in adults and children.

GNH USA supplies Dupixent 200 mg/1.14mL as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

What is Dupilumab used for?

Dupixent 200 mg/1.14mL is primarily used to manage inflammatory conditions by targeting specific pathways involved in inflammation. It is prescribed for the following conditions:

- Moderate-to-severe atopic dermatitis (eczema): Reduces symptoms and improves quality of life in adults and children. - Asthma: Used as an add-on treatment for severe asthma not adequately controlled by other medications. - Chronic rhinosinusitis with nasal polyps: Helps manage symptoms when other treatments have not been effective.

What are the side effects of Dupilumab?

Dupixent 200 mg/1.14mL may cause several side effects, ranging from common to serious. Common Side Effects: - Injection site reactions - Eye and eyelid inflammation - Cold symptoms - Joint pain - Temporary increase in eosinophils

Serious or Rare Side Effects: - Allergic reactions, including anaphylaxis - Conjunctivitis and keratitis - Herpes zoster - Joint pain and mobility issues - Elevated liver enzymes

What precautions apply to Dupilumab?

Dupixent should be used with caution and under the guidance of a healthcare provider. Important precautions include: - Inform your healthcare provider about all medications you are taking, especially those that suppress the immune system. - Avoid using live vaccines while on Dupixent without medical advice. - Monitor for signs of allergic reactions or infections. - Use exactly as prescribed and do not shake the syringe before use. - Store at room temperature: Protect from light and do not freeze.

What does Dupilumab interact with?

Dupixent may interact with other medications, particularly those that affect the immune system. Major Interactions (Avoid): - Live vaccines: Avoid concurrent use due to potential reduced vaccine efficacy and increased risk of infection. - Biologic therapies: May increase the risk of infections when used together.

Moderate Interactions (Monitor Closely): - Systemic corticosteroids: Monitor for signs of infection or reduced efficacy. - Other immunosuppressants: Increased risk of infections and other immune-related side effects.

Frequently asked questions

What is Dupixent 200 mg/1.14mL used for?+
Dupixent 200 mg/1.14mL is used to treat moderate-to-severe atopic dermatitis (eczema), asthma, and chronic rhinosinusitis with nasal polyps. It works by targeting specific pathways involved in inflammation, helping to reduce symptoms and improve quality of life.
How does Dupilumab work?+
Dupilumab, the active ingredient in Dupixent, binds to the IL-4Rα subunit, blocking the signaling of interleukins 4 and 13. This action reduces type 2 inflammatory responses, which are involved in conditions like atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps.
What is the usual dose of Dupixent?+
The dosage of Dupixent is determined by a healthcare provider based on the patient's condition, age, and weight. It is typically administered as a subcutaneous injection, with the specific dosing regimen prescribed by the doctor.
Is Dupixent safe during pregnancy or breastfeeding?+
The safety of Dupixent during pregnancy or breastfeeding has not been fully established. It is important to consult with a healthcare provider to discuss the potential risks and benefits before using Dupixent in these situations.
How do I order Dupixent from GNH USA?+
To order Dupixent from GNH USA, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then provide pricing, availability, shipping, and the necessary import paperwork.
How does Dupixent compare to other treatments for atopic dermatitis?+
Dupixent is a biologic therapy that targets specific inflammatory pathways, making it effective for moderate-to-severe atopic dermatitis. Compared to topical treatments, it offers a systemic approach that can be more effective for widespread or severe symptoms. However, the choice of treatment depends on individual patient needs and should be discussed with a healthcare provider.
How should Dupixent be stored and handled?+
Dupixent should be stored at room temperature and protected from light. It is important not to shake the syringe before use. Always follow the instructions provided by your healthcare provider for proper administration and storage.
How is Dupixent administered?+
Dupixent is administered as a subcutaneous injection. It can be injected into the thigh, abdomen (except within 5 cm of the navel), or upper arm if administered by another person. The injection site should be rotated with each use, and the medication should not be injected into damaged or irritated skin.
What are the most serious risks associated with Dupixent?+
The most serious risks associated with Dupixent include allergic reactions, such as anaphylaxis, and infections. Patients should be monitored for signs of infection or allergic reactions and should seek immediate medical attention if severe symptoms occur.
Who should not use Dupixent?+
Dupixent should not be used by individuals with a known hypersensitivity to dupilumab or any of its components. It should also be used with caution in patients with a history of parasitic infections or those who are immunocompromised. Always consult a healthcare provider before starting Dupixent.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Dupilumab
Brand
Dupixent
Strength
200 mg/1.14mL
Form
INJECTION, SOLUTION
Route
SUBCUTANEOUS
Pack size
2 SYRINGE, GLASS in 1 CARTON (0024-5919-20) / 1.14 mL in 1 SYRINGE, GLASS (0024-5919-01)
Manufacturer
sanofi-aventis U.S. LLC
Origin
USA

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