GNH USA

Europe — EMA

No-Spa Ampułki (Drotaverine Hydrochloride)

GNH USA supplies No-Spa Ampułki (Drotaverine Hydrochloride), a antispasmodic for abdominal, biliary and menstrual cramps. Request a quote for global supply.

Drotaverine Hydrochloride

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What is Drotaverine Hydrochloride?

Drotaverine Hydrochloride, the active ingredient in No-Spa Ampułki, is an antispasmodic presented as an injectable solution (ampoule) for intramuscular, intravenous or subcutaneous use. It relieves smooth‑muscle spasm in abdominal, biliary, menstrual and urological conditions.

GNH USA supplies No-Spa Ampułki as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Drotaverine Hydrochloride used for?

Drotaverine Hydrochloride is employed to manage smooth‑muscle spasm across several gastrointestinal and genitourinary disorders.

- Abdominal and gastrointestinal spasm: reduces painful contractions and facilitates normal motility. - Biliary colic: relaxes the sphincter of Oddi and eases bile duct pain. - Menstrual cramps: alleviates uterine muscle cramps during dysmenorrhea. - Urological spasm: eases bladder neck and ureteral smooth‑muscle tension.

What are the side effects of Drotaverine Hydrochloride?

Adverse reactions may occur following administration of No-Spa Ampułki.

Common Side Effects: - Dizziness: transient sensation of light‑headedness. - Headache: mild to moderate intensity. - Nausea: occasional upset stomach. - Flushing: temporary reddening of skin. - Hypotension: mild drop in blood pressure. - Injection site pain: local discomfort at the puncture site.

Serious or Rare Side Effects: - Allergic reactions: rash, pruritus, or urticaria. - Anaphylaxis: severe, potentially life‑threatening hypersensitivity. - Severe hypotension: marked blood pressure fall requiring intervention. - Cardiac arrhythmia: irregular heart rhythm. - Hematologic abnormalities: rare blood‑cell disturbances. - Hepatic dysfunction: uncommon liver enzyme elevation.

What precautions apply to Drotaverine Hydrochloride?

Prior to using No-Spa Ampułki, clinicians should consider several safety aspects.

- Cardiovascular assessment: evaluate blood pressure and heart status. - Hepatic impairment: use with caution in patients with liver disease. - Renal impairment: monitor renal function and adjust if necessary. - Allergic history: avoid in individuals with known hypersensitivity to drotaverine. - Concomitant hypotensive agents: watch for additive blood‑pressure lowering effects. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Drotaverine Hydrochloride interact with?

Drotaverine Hydrochloride may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase drotaverine plasma levels. - Co‑administration with other antispasmodics: risk of excessive smooth‑muscle relaxation.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect. - Antihypertensive drugs: potential additive hypotensive effect. - Diuretics: may enhance blood‑pressure lowering and electrolyte shifts. - Antihistamines: possible increase in sedation or dizziness. - NSAIDs: monitor for gastrointestinal irritation when combined.

Frequently asked questions

What is No-Spa Ampułki used for?+
No-Spa Ampułki contains drotaverine hydrochloride and is indicated for the relief of smooth‑muscle spasm in the abdomen, biliary tract, uterus during menstrual cramps, and the urinary system. It is commonly used to treat abdominal colic, biliary colic, dysmenorrhea and certain urological spasms.
How does Drotaverine Hydrochloride work?+
Drotaverine Hydrochloride blocks phosphodiesterase‑4, which raises intracellular cyclic AMP levels. The increased cAMP reduces calcium influx in smooth‑muscle cells, leading to relaxation of the muscle fibers without significant anticholinergic activity, thereby easing spasm and pain.
What is the usual dose of No-Spa Ampułki?+
The exact dose of No-Spa Ampułki is determined by the prescribing clinician based on the patient’s condition, age, weight and response. Typical adult regimens involve a single ampoule administered intravenously, intramuscularly or subcutaneously, with possible repeat dosing as medically indicated.
Is No-Spa Ampułki safe during pregnancy or breastfeeding?+
Safety data for drotaverine hydrochloride in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order No-Spa Ampułki from GNH USA?+
To order No-Spa Ampułki, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.
How does No-Spa compare with other antispasmodic drugs?+
Compared with anticholinergic agents such as hyoscine, drotaverine offers smooth‑muscle relaxation without significant dry‑mouth or blurred‑vision side effects. Unlike papaverine, it has a more predictable pharmacokinetic profile and fewer cardiovascular effects, making it a preferred option for many clinicians treating abdominal and biliary colic.
How should No-Spa Ampułki be stored and handled?+
No-Spa Ampułki must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the ampoules. Before use, allow the product to reach room temperature if required, and handle with aseptic technique to maintain sterility.
How is No-Spa Ampułki administered?+
The ampoules are intended for parenteral use. They can be given intravenously, intramuscularly or subcutaneously by a qualified healthcare professional. The injection site and route are selected based on the clinical situation and patient tolerance.
What are the most serious risks to watch for with No-Spa Ampułki?+
Serious risks include severe allergic reactions such as anaphylaxis, marked hypotension that may require medical intervention, and rare cardiac arrhythmias. Patients should be monitored for signs of hypersensitivity, sudden blood‑pressure drops or irregular heartbeats during and after administration.
Who should not use No-Spa Ampułki?+
No-Spa Ampułki is contraindicated in individuals with known hypersensitivity to drotaverine or any excipients in the formulation. Caution is advised for patients with severe cardiovascular instability, uncontrolled hypotension, or those receiving other potent vasodilators.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Drotaverine Hydrochloride
Route
Intramuscular Use , Intravenous Use , Subcutaneous
Manufacturer
Opella Healthcare Commercial Kft.
Origin
EU

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