Europe — EMA
Mikronizované Flavonoidy (Diosmin)
GNH USA supplies Mikronizované Flavonoidy (Diosmin), a flavonoid vasoprotective agent for chronic venous insufficiency and hemorrhoids.
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What is Diosmin?
Diosmin, the active ingredient in Mikronizované Flavonoidy, is a flavonoid (vasoprotective agent) presented as a micronized oral formulation for oral use. It is employed to support vascular health in adults with chronic venous insufficiency and hemorrhoidal disease.
GNH USA supplies Mikronizované Flavonoidy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Diosmin used for?
Mikronizované Flavonoidy acts on the venous and microcirculatory system to improve vascular tone and reduce edema. - Chronic venous insufficiency: enhances venous return and lessens leg heaviness and swelling. - Hemorrhoidal disease: decreases venous congestion, reducing bleeding and discomfort. - Varicose veins: supports reduction of leg pain, edema and improves overall limb comfort.
What are the side effects of Diosmin?
Mikronizované Flavonoidy is generally well tolerated, but adverse reactions can occur.
Common Side Effects: - Gastrointestinal discomfort: mild abdominal pain or upset stomach. - Nausea: occasional feeling of queasiness. - Headache: transient mild headache. - Dizziness: light‑headed sensation.
Serious or Rare Side Effects: - Severe allergic reaction: rash, swelling, difficulty breathing. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Thrombocytopenia: unusually low platelet count.
What precautions apply to Diosmin?
Before initiating therapy, consider the following precautions. - Renal or hepatic impairment: assess function and monitor periodically. - Bleeding disorders: use with caution due to potential impact on coagulation. - Known hypersensitivity: avoid if allergic to flavonoids. - Pregnancy and lactation: safety not established; consult a healthcare professional. - Do not exceed prescribed amount: follow prescriber instructions. - Store at ambient temperature: keep in the original pack, protect from moisture.
What does Diosmin interact with?
Diosmin may interact with several medication classes.
Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - NSAIDs: additive gastrointestinal irritation.
Moderate Interactions (Monitor Closely): - Antihypertensives: possible additive blood‑pressure lowering effect. - Antiplatelet agents: enhanced antithrombotic activity. - Oral contraceptives: potential alteration of hormone metabolism.



