Lenoxin®

Digoxin, the active ingredient in Lenoxin®, is a cardiac glycoside presented as an oral dosage form for oral use. It is used to improve cardiac contractility and control heart rate in patients with heart failure and atrial fibrillation. GNH USA supplies Lenoxin® as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Digoxin acts on the cardiac conduction system and myocardial contractility to treat specific cardiovascular conditions.

Heart failure: improves cardiac output and reduces symptoms of fluid overload. Atrial fibrillation: helps control ventricular rate and restores sinus rhythm in selected patients.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects: - Nausea or vomiting - Diarrhea - Fatigue or weakness - Dizziness or light‑headedness - Blurred or yellow‑green vision - Headache

Serious or Rare Side Effects: - Life‑threatening arrhythmias (e.g., ventricular tachycardia) - Severe bradycardia or heart block - Hyperkalemia - Allergic reactions such as rash or angioedema - Persistent visual disturbances (e.g., halos) - Confusion or hallucinations

Before initiating digoxin therapy, several safety considerations are recommended.

Monitor serum digoxin levels: adjust dose based on therapeutic range. Assess renal function: dose reduction may be needed in impairment. Correct electrolyte abnormalities: especially potassium, magnesium, and calcium. Avoid use in patients with ventricular fibrillation or advanced AV block without a pacemaker. Use with caution during pregnancy and lactation; benefits must outweigh potential risks. Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Digoxin has a narrow therapeutic index and interacts with several medicines.

Major Interactions (Avoid): - Amiodarone: markedly increases digoxin concentrations. - Quinidine: raises serum digoxin levels and risk of toxicity. - Verapamil: enhances digoxin effect and may cause bradycardia.

Moderate Interactions (Monitor Closely): - Thiazide diuretics: may cause electrolyte shifts that predispose to toxicity. - ACE inhibitors: can increase digoxin levels modestly. - NSAIDs: may reduce renal clearance of digoxin, necessitating monitoring.