GNH USA

Europe — EMA

Isopto®-Dex

GNH USA supplies Isopto-Dex (Dexamethasone), a corticosteroid for postoperative ocular inflammation, uveitis and anterior segment inflammation.

Dexamethasone

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What is Dexamethasone?

Dexamethasone, the active ingredient in Isopto-Dex, is a corticosteroid presented as a 0.1% w/v ophthalmic suspension for ocular (topical) use. It treats postoperative ocular inflammation, uveitis, and anterior segment inflammation in patients requiring anti‑inflammatory therapy.

GNH USA supplies Isopto-Dex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Dexamethasone used for?

Isopto-Dex, a topical corticosteroid, is used to manage inflammatory conditions of the anterior eye segment.

Postoperative ocular inflammation: reduces swelling, pain and redness after eye surgery. Uveitis: controls intra‑ocular inflammation and helps prevent tissue damage. Anterior segment inflammation: alleviates redness, edema and discomfort in conditions such as iritis.

What are the side effects of Dexamethasone?

Common Side Effects: - Eye irritation or burning sensation. - Transient increase in intra‑ocular pressure. - Blurred vision. - Tearing or watery eyes. - Foreign body sensation. - Conjunctival hyperemia.

Serious or Rare Side Effects: - Cataract formation with prolonged use. - Secondary ocular infection (bacterial, fungal, or viral). - Glaucoma due to sustained pressure elevation. - Delayed wound healing after ocular surgery. - Retinal detachment (very rare).

What precautions apply to Dexamethasone?

Before using Isopto-Dex, consider the following precautions.

Monitor intra‑ocular pressure: schedule regular IOP checks during therapy. Avoid use in active viral eye infections: may worsen the condition. Use cautiously in patients with a history of glaucoma. Do not wear contact lenses while administering the suspension. Discontinue if signs of ocular infection appear. Store at room temperature: keep in the original container, protect from light and moisture.

What does Dexamethasone interact with?

Isopto-Dex may interact with other ocular or systemic agents.

Major Interactions (Avoid): - Systemic corticosteroids: additive systemic glucocorticoid effects. - Antifungal eye drops: may reduce antifungal efficacy.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory eye drops: potential increase in intra‑ocular pressure. - Beta‑blocker eye drops: possible additive ocular hypotensive effect. - Live vaccines: systemic immunosuppression could diminish vaccine response.

Frequently asked questions

What conditions is Isopto-Dex used for?+
Isopto-Dex is prescribed to manage postoperative ocular inflammation, uveitis, and inflammation of the anterior segment of the eye. It helps reduce swelling, pain, and redness associated with these conditions by delivering a corticosteroid directly to the eye surface.
How does dexamethasone work in Isopto-Dex?+
Dexamethasone acts as a glucocorticoid receptor agonist. After binding to receptors inside ocular cells, it alters gene expression to suppress inflammatory mediators, decrease leukocyte migration, and stabilise cellular membranes, thereby reducing inflammation and immune activity in the eye.
What is the usual dose of Isopto-Dex?+
The specific dosing regimen for Isopto-Dex is determined by the prescribing ophthalmologist based on the severity of the condition, patient response, and treatment duration. The prescriber will provide detailed instructions on the number of drops and frequency.
Is Isopto-Dex safe to use during pregnancy or breastfeeding?+
The safety of Isopto-Dex in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when appropriate.
How do I order Isopto-Dex from GNH USA?+
To request Isopto-Dex, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Isopto-Dex compare with other ocular corticosteroids?+
Isopto-Dex contains dexamethasone, a potent corticosteroid with a rapid anti‑inflammatory onset. Compared with weaker agents like prednisolone acetate, dexamethasone often requires a shorter treatment course but may carry a higher risk of intra‑ocular pressure elevation, necessitating careful monitoring.
What are the storage requirements for Isopto-Dex?+
Isopto-Dex should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any suspension that has changed in appearance or is past its expiration date.
How is Isopto-Dex administered?+
Isopto-Dex is applied as an ophthalmic suspension. The patient tilts the head back, gently pulls down the lower eyelid, and instills the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow even distribution.
What are the most serious risks associated with Isopto-Dex?+
Serious risks include a significant rise in intra‑ocular pressure leading to glaucoma, cataract formation with prolonged use, and secondary ocular infections. Patients should be monitored regularly for visual changes, pressure spikes, and signs of infection.
Who should not use Isopto-Dex?+
Isopto-Dex is contraindicated in patients with known hypersensitivity to dexamethasone or any component of the formulation, and it should be avoided in active viral ocular infections such as herpes simplex keratitis. Caution is also advised for individuals with uncontrolled glaucoma.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.

Product details

Drug
Dexamethasone
Route
Ocular Use
Manufacturer
Novartis Pharma Gmbh
Origin
EU

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