Kolomycín

Colistimethate Sodium, the active ingredient in Kolomycín, is a polymyxin presented as a sterile solution for inhalation, intramuscular, and intravenous use. It treats serious infections caused by susceptible Gram‑negative bacteria, notably Pseudomonas aeruginosa, including in cystic fibrosis patients.

GNH USA supplies Kolomycín as a licensed, GDP‑compliant international pharmaceutical supplier, ensuring quality and regulatory compliance while serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. Our distribution network provides reliable delivery and support for critical antimicrobial therapies across Europe, Asia, Africa and the Americas.

Kolomycín, a polymyxin antibiotic, is used to combat serious Gram‑negative bacterial infections. - Serious Gram‑negative bacterial infections: effective against multidrug‑resistant strains. - Pseudomonas aeruginosa infections: employed for lung infections in cystic fibrosis patients. - Ventilator‑associated pneumonia: administered intravenously for severe cases.

Adverse reactions may occur with Kolomycín therapy.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Diarrhea: loose stools that may be watery. - Rash: skin redness or itching. - Headache: transient head discomfort.

Serious or Rare Side Effects: - Nephrotoxicity: impaired kidney function requiring monitoring. - Neurotoxicity: seizures or altered mental status. - Allergic reactions: anaphylaxis or severe skin eruptions. - Ototoxicity: hearing loss or balance disturbances.

Kolomycín requires careful monitoring and specific handling precautions. - Renal function: assess and monitor patients with impaired kidneys. - Neurological status: observe for signs of neurotoxicity such as seizures. - Pregnancy: use only if the potential benefit justifies the potential risk. - Concomitant nephrotoxic drugs: avoid or adjust dosage to reduce kidney injury. - Allergy: discontinue immediately if hypersensitivity develops. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Kolomycín may interact with other medications, influencing safety and efficacy.

Major Interactions (Avoid): - Aminoglycosides: increased risk of nephrotoxicity. - Loop diuretics: enhanced renal toxicity. - Neuromuscular blockers: heightened risk of respiratory paralysis.

Moderate Interactions (Monitor Closely): - Vancomycin: additive nephrotoxic potential. - Cisplatin: increased renal risk. - NSAIDs: may exacerbate kidney dysfunction.