COLESEVELAM HYDROCHLORIDE 625 mg/1

Colesevelam Hydrochloride, the active ingredient in COLESEVELAM HYDROCHLORIDE, is a bile acid sequestrant presented as a 625 mg film-coated tablet for oral use. It is used to lower LDL cholesterol in adults with primary hypercholesterolemia and to improve glycemic control in adults with type 2 diabetes.

GNH USA supplies COLESEVELAM HYDROCHLORIDE as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

COLESEVELAM HYDROCHLORIDE is a bile acid sequestrant used to manage cholesterol levels and blood sugar.

- Primary hypercholesterolemia: Reduces elevated low-density lipoprotein (LDL) cholesterol levels. - Heterozygous familial hypercholesterolemia: Helps manage inherited high cholesterol. - Hyperlipidemia: Lowers levels of fats in the blood. - Type 2 diabetes mellitus: Improves glycemic control as an adjunct to diet and exercise.

COLESEVELAM HYDROCHLORIDE may cause several side effects, ranging from mild to serious.

Common Side Effects: - Constipation - Indigestion and upset stomach - Nausea - Runny nose, sore throat, and other respiratory symptoms - Muscle aches

Serious or Rare Side Effects: - Pancreatitis: Severe abdominal pain that may radiate to the back, with or without nausea and vomiting. - Bowel obstruction: Symptoms include inability to pass gas or stool and a hard, swollen abdomen. - Vitamin deficiency: May interfere with the absorption of fat-soluble vitamins such as A, D, E, and K.

COLESEVELAM HYDROCHLORIDE should be used with caution and under medical supervision.

- Dosage timing: Take each dose with a meal and 8 ounces of liquid to ensure proper movement through the digestive system. - Hypertriglyceridemia: Avoid in patients with high triglyceride levels as it may cause further increases. - Bowel obstruction: Use with caution in patients with a history of bowel surgery or severe constipation. - Vitamin deficiency: Take multivitamins and supplements containing fat-soluble vitamins at least 4 hours before taking COLESEVELAM HYDROCHLORIDE. - Store below 25°C: Keep in the original pack, protect from moisture.

COLESEVELAM HYDROCHLORIDE may interact with other medications, requiring careful monitoring or dosage adjustments.

Major Interactions (Avoid): - Blood thinners: Can affect levels of blood thinners like warfarin, necessitating more frequent blood monitoring. - Thyroid medications: May bind to levothyroxine and other thyroid hormones, leading to hypothyroidism if doses are not separated.

Moderate Interactions (Monitor Closely): - Vitamins: Take multivitamins and supplements containing fat-soluble vitamins at least 4 hours before taking COLESEVELAM HYDROCHLORIDE. - Oral birth control: May lose effectiveness if taken too close to a COLESEVELAM HYDROCHLORIDE dose. - Diabetes medications: May interfere with the absorption of diabetes medications like glimepiride and glipizide.