Oрадро (Clarithromycin)

Clarithromycin, the active ingredient in Oрадро, is a macrolide antibiotic presented as a tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, skin infections and certain atypical mycobacterial diseases in adults and children when prescribed by a healthcare professional.

GNH USA supplies Oрадро as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Clarithromycin is a macrolide antibiotic that acts on a range of bacterial respiratory, skin and soft‑tissue infections. - Community‑acquired bacterial pneumonia: helps eradicate the causative pathogens and improve clinical recovery. - Acute bacterial sinusitis: reduces bacterial load and alleviates sinus inflammation. - Skin and soft‑tissue infections (e.g., cellulitis, erythema): assists in eliminating susceptible organisms and promotes healing.

Clarithromycin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhea: loose stools, often transient. - Abdominal pain: cramping or discomfort. - Taste disturbance: altered or metallic taste. - Headache: mild headache. - Rash: mild skin erythema.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis): difficulty breathing, swelling, hives. - Hepatotoxicity: elevated liver enzymes, jaundice. - Cardiac arrhythmias (QT prolongation): palpitations, fainting. - Clostridioides difficile infection: severe colitis with watery diarrhea. - Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.

Before prescribing clarithromycin, consider patient‑specific factors and monitor for potential adverse events. - Hepatic impairment: dose adjustment may be required; monitor liver function tests. - Renal impairment: assess kidney function; adjust dose in severe cases. - Concomitant QT‑prolonging drugs: avoid or monitor ECG for arrhythmia risk. - Pregnancy and lactation: use only if clearly needed; discuss risks with obstetrician. - Drug‑resistant infections: verify susceptibility before long‑term use. - Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture and direct sunlight.

Clarithromycin interacts with several medicines through cytochrome P450 inhibition and additive cardiac effects.

Major Interactions (Avoid): - Statins (e.g., simvastatin, lovastatin): risk of rhabdomyolysis. - Warfarin: increased anticoagulant effect, heightened bleeding risk. - Pimozide: may cause severe QT prolongation.

Moderate Interactions (Monitor Closely): - Carbamazepine: reduced clarithromycin levels, possible loss of efficacy. - Digoxin: increased serum digoxin concentrations. - Oral hypoglycemics (e.g., sulfonylureas): enhanced hypoglycaemic effect.