Levofolinato De Cálcio Farmoz

Calcium levofolinate, the active ingredient in Levofolinato De Cálcio Farmoz, is a folate analog presented as an injectable solution for intramuscular and intravenous use. It rescues normal cells from antifolate toxicity and enhances the cytotoxic effect of 5‑fluorouracil in oncology patients.

GNH USA supplies Levofolinato De Cálcio Farmoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Levofolinato De Cálcio Farmoz is a folate analog used in oncology and metabolic support. - Methotrexate toxicity rescue: reduces toxicity in patients receiving high‑dose methotrexate. - Enhancement of 5‑fluorouracil chemotherapy: increases cytotoxic efficacy of 5‑FU in solid‑tumour regimens. - Folate deficiency: provides reduced folate cofactor to correct severe folate shortage.

Adverse reactions may vary with dose, route and patient factors.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Transient flushing: brief sensation of warmth or redness. - Mild rash: localized skin erythema. - Low‑grade fever: temporary temperature elevation.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Acute renal toxicity: sudden decline in kidney function. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Severe hypotension: marked drop in blood pressure. - Pulmonary edema: fluid accumulation in the lungs. - Electrolyte disturbances: significant shifts in potassium or calcium levels.

Use of calcium levofolinate requires careful clinical assessment. - Renal function: evaluate creatinine clearance before each dose. - Hepatic impairment: monitor liver enzymes and adjust if necessary. - Pregnancy: prescribe only when potential benefit outweighs unknown fetal risk. - Concurrent antifolate therapy: avoid simultaneous high‑dose methotrexate without rescue. - Allergy history: discontinue if hypersensitivity signs appear. - Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Calcium levofolinate may interact with several drug classes.

Major Interactions (Avoid): - High‑dose methotrexate: concurrent use without rescue increases toxicity. - Nephrotoxic agents (e.g., cisplatin): may exacerbate renal injury. - Live vaccines: reduced efficacy due to folate pathway modulation.

Moderate Interactions (Monitor Closely): - NSAIDs: can diminish renal clearance of levofolinate. - Proton pump inhibitors: may alter folate metabolism. - Sulfonamides: compete for renal tubular secretion, affecting plasma levels.