Liorésal

Baclofen, the active ingredient in Liorésal, is a GABA_B receptor agonist presented as an oral tablet for oral use. It is indicated for the management of spasticity associated with multiple sclerosis, spinal cord injury, cerebral palsy and other spastic movement disorders.

GNH USA supplies Liorésal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Liorésal (baclofen) acts on the central nervous system to reduce abnormal muscle tone in several neurological conditions.

- Multiple sclerosis‑related spasticity: decreases muscle stiffness and improves mobility. - Spinal cord injury‑related spasticity: reduces involuntary muscle contractions. - Cerebral palsy: lessens spastic movement and facilitates physiotherapy. - Other spastic movement disorders: provides general antispastic benefit.

Baclofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness - Drowsiness or fatigue - Weakness or muscle hypotonia - Nausea or gastrointestinal upset - Headache - Dry mouth

Serious or Rare Side Effects: - Seizures or convulsions - Hallucinations or psychosis - Severe hypotension or cardiovascular collapse - Respiratory depression - Anaphylactic or severe allergic reactions - Cardiac arrhythmias

When prescribing Liorésal, clinicians should consider several safety factors.

- Renal impairment: adjust dose as baclofen is renally excreted. - Hepatic impairment: monitor for increased plasma levels. - Abrupt discontinuation: taper to avoid withdrawal symptoms. - Pregnancy Category C: weigh potential benefits against risks. - Lactation: baclofen may be excreted in breast milk. - Elderly patients: start with lower doses due to increased sensitivity. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Baclofen can interact with other medications, requiring careful management.

Major Interactions (Avoid): - CNS depressants (alcohol, opioids, benzodiazepines): may enhance sedation and respiratory depression. - Antihypertensive agents: additive hypotensive effect.

Moderate Interactions (Monitor Closely): - Diuretics: may increase risk of hypotension. - Antidiabetic drugs: monitor blood glucose as baclofen can affect glycemic control. - CYP450 inhibitors or inducers: may alter baclofen plasma concentrations. - Anticholinergic agents: may exacerbate constipation.