Nefúði, Dreifa (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride, the active ingredient in Nefúði, Dreifa, is an antihistamine presented as a nasal spray for intranasal use. It is combined with fluticasone propionate, a corticosteroid, to treat allergic rhinitis in patients who need both antihistamine and anti‑inflammatory action.

GNH USA supplies Nefúði, Dreifa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nefúði, Dreifa combines azelastine hydrochloride and fluticasone propionate to treat allergic rhinitis, an IgE‑mediated nasal inflammation. - Allergic rhinitis: reduces nasal congestion, itching, sneezing and rhinorrhoea. - Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or other seasonal allergens. - Perennial allergic rhinitis: controls year‑round nasal inflammation caused by indoor allergens.

Nefúði, Dreifa may cause local and systemic adverse reactions.

Common Side Effects: - Nasal irritation or burning sensation. - Headache. - Bitter taste. - Epistaxis (nosebleed). - Cough. - Throat irritation.

Serious or Rare Side Effects: - Nasal septal perforation. - Severe allergic reaction (anaphylaxis). - Vision changes or increased intra‑ocular pressure. - Adrenal suppression with prolonged high‑dose use. - Secondary infection of the nasal mucosa.

Before using Nefúði, Dreifa, consider the following precautions. - Pregnancy: consult a healthcare professional before use. - Breastfeeding: discuss potential risks with a physician. - Concomitant intranasal corticosteroids: avoid to reduce systemic exposure. - Glaucoma or cataract: monitor intra‑ocular pressure regularly. - Children and adolescents: follow local prescribing guidelines. - Store at room temperature: keep in the original container, protect from moisture and light.

Nefúði, Dreifa can interact with other medicines; monitor as indicated.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase fluticasone levels. - Live vaccines: may reduce vaccine efficacy. - Concurrent use of other intranasal corticosteroids: risk of systemic corticosteroid effects.

Moderate Interactions (Monitor Closely):\n- Other antihistamines: possible additive sedation. - Beta‑blockers: may mask symptoms of severe allergic reactions. - Alcohol: may increase nasal irritation or dryness.